ArticleScientific reports2017
Ultraviolet Radiation-Induced Production of Nitric Oxide:A multi-cell and multi-donor analysis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Effects of ultraviolet light exposure on blood pressure: a systematic review.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Pooled it
- Application of medical gases in prevention and treatment of electromagnetic radiation injury.Medical gas research · 2027Review
- Assessment of Nitric Oxide Release In Vitro via Low-Level Daylight-Equivalent Blue or Red Light Irradiation.Antioxidants (Basel, Switzerland) · 2026Article
- Engineering a Human-Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation.Advanced healthcare materials · 2025Article
- Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway.Experimental & molecular medicine · 2024Article
- Low-dose daylight exposure induces nitric oxide release and maintains cell viability in vitro.Scientific reports · 2023Article
- Non-Melanoma Skin Cancer and Vitamin D: The "Lost Sunlight" Paradox and the Oxidative Stress Explanation.Antioxidants (Basel, Switzerland) · 2023Article
- Long-term residential sunlight exposure associated with cognitive function among adults residing in Finland.Scientific reports · 2022Article
- Isolation of five different primary cell types from a single sample of human skin.STAR protocols · 2022Article
- Post-exposure persistence of nitric oxide upregulation in skin cells irradiated by UV-A.Scientific reports · 2022Article
- Regulatory Role of Nitric Oxide in Cutaneous Inflammation.Inflammation · 2022Review
- Analysis of the Seasonal Fluctuation of γδ T Cells and Its Potential Relation with Vitamin DCells · 2022Article
- Role of nitric oxide in regulating epidermal permeability barrier function.Experimental dermatology · 2022Review
- Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants.Antioxidants (Basel, Switzerland) · 2022Review
- The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro.Scientific reports · 2021Article
- Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes.Particle and fibre toxicology · 2021Article
- Temporal patterns of suicide and circulatory system disease-related mortality are inversely correlated in several countries.BMC psychiatry · 2021Article
- Synthetic, Natural, and Semisynthetic Polymer Carriers for Controlled Nitric Oxide Release in Dermal Applications: A Review.Polymers · 2021Review
- Light-Mediated Inhibition of Colonic Smooth Muscle Constriction and Colonic MotilityFrontiers in physiology · 2021Article
- State-of-the-art and current challenges for TiOEnvironmental science and pollution research international · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence regarding positive effects of exposure to sunlight has led to suggestions that current advice may be overly weighted in favour of avoidance. UV-A has been reported to lower blood pressure, possibly through nitric oxide (NO) production in skin. Here, we set out to investigate effects of UV-A and solar-simulated radiation on the potential source of dermal NO, the effective doses and wavelengths, the responsiveness of different human skin cells, the magnitude of inter-individual differences and the potential influence of age. We utilised isogenic keratinocytes, microvascular endothelial cells, melanocytes and fibroblasts isolated from 36 human skins ranging from neonates to 86 years old. We show that keratinocytes and microvascular endothelial cells show greatest NO release following biologically relevant doses of UV-A. This was consistent across multiple neonatal donors and the effect is maintained in adult keratinocytes. Our observations are consistent with a bi-phasic mechanism by which UV-A can trigger vasodilatory effects. Analyses of NO-production spectra adds further evidence that nitrites in skin cells are the source of UV-mediated NO release. These potentially positive effects of ultraviolet radiation lend support for objective assessment of environmental influence on human health and the idea of "healthy sun exposure".
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.