ArticleScientific reports2017
Sexual congruency in the connectome and translatome of VTA dopamine neurons.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Stress resilience is associated with transcriptional remodeling in the VTA.Cell reports · 2026Article
- Stress resilience is associated with transcriptional remodeling in the VTA.bioRxiv : the preprint server for biology · 2025Article
- Interactions of sex and stress in modulation of ventral tegmental area dopaminergic activity.Current opinion in behavioral sciences · 2025Article
- Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation.Cell reports · 2024Article
- Activation of CGRP neurons in the parabrachial nucleus suppresses addictive behavior.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neuropeptides Modulate Feeding via the Dopamine Reward Pathway.Neurochemical research · 2023Review
- Temporal scaling of dopamine neuron firing and dopamine release by distinct ion channels shape behavior.Science advances · 2023Article
- Article
- Sex differences in VTA GABA transmission and plasticity during opioid withdrawal.Scientific reports · 2023Article
- Sex differences in learning and performing the Go/NoGo tasks.Biology of sex differences · 2023Article
- A Critical Involvement of Glutamatergic Neurons in the Anterior Insular Cortex for Subdiaphragmatic Vagotomy-induced Analgesia.Experimental neurobiology · 2023Article
- Article
- Sex differences in chronic pain-induced mental disorders: Mechanisms of cerebral circuitry.Frontiers in molecular neuroscience · 2023Review
- The potassium channel auxiliary subunit Kvβ2 (Journal of neurophysiology · 2022Article
- Article
- Distinct Encoding of Reward and Aversion by Peptidergic BNST Inputs to the VTA.Frontiers in neural circuits · 2022Article
- Autism-associated mutations in KProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons.Cold Spring Harbor perspectives in medicine · 2021Review
- Sex and strain differences in dynamic and static properties of the mesolimbic dopamine system.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Neural and Hormonal Control of Sexual Behavior.Endocrinology · 2020Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The ventral tegmental area (VTA) dopamine system is important for reward, motivation, emotion, learning, and memory. Dysfunctions in the dopamine system are linked to multiple neurological and neuropsychiatric disorders, many of which present with sex differences. Little is known about the extent of heterogeneity in the basic organization of VTA dopamine neurons with regard to sex. Here, we characterized the cell-specific connectivity of VTA dopamine neurons, their mRNA translational profile, and basic electrophysiological characteristics in a common strain of mice. We found no major differences in these metrics, except for differential expression of a Y-chromosome associated mRNA transcript, Eif2s3y, and the X-linked, X-inactivation transcript Xist. Of note, Xist transcript was significantly enriched in dopamine neurons, suggesting tight regulation of X-linked gene expression to ensure sexual congruency. These data indicate that the features that make dopamine neurons unique are highly concordant and not a principal source of sexual dimorphism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.