SynthesisScientific reports2017
The association of young age with local recurrence in women with early-stage breast cancer after breast-conserving therapy: a meta-analysis.
Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- The incidence, clinicopathological characteristics and the survival outcomes among young breast cancer patients in Alexandria, Egypt.Ecancermedicalscience · 2026Article
- Rising Breast Cancer Incidence and Poor Outcomes in Young Women: A Retrospective Study.The breast journal · 2026Article
- A preoperative nomogram incorporating semantic MRI features for predicting breast cancer recurrence: a propensity score-matched cohort study.Frontiers in oncology · 2026Article
- Comparing Survival Differences between Patients Undergoing Breast-Conserving Therapy Versus Total Mastectomy as a First Treatment for Early Stage Breast Cancer.Annals of surgical oncology · 2025Article
- Preoperative Predictors of Subsequent Breast Cancer Events Detected on Abbreviated MRI in Patients with Early-Stage Breast Cancer.Diagnostics (Basel, Switzerland) · 2025Article
- TMB as a predictive biomarker for ICI response in TNBC: current evidence and future directions for augmented anti-tumor responses.Clinical and experimental medicine · 2025Review
- Co-targeting CDK4/6 enhances anti-cancer activity and alleviates immune-related adverse events of anti-PD-1 antibody for breast cancer.Cell reports. Medicine · 2025Article
- Long-Term Locoregional Outcomes in a Contemporary Cohort of Young Women With Breast Cancer.JAMA surgery · 2025Article
- First mammogram-detected cancers portend worse survival in young women diagnosed with breast cancer.Breast cancer research and treatment · 2025Article
- Illuminating Bilateral Breast Cancer: A Multicenter Experience and Clinical Observations.Medicina (Kaunas, Lithuania) · 2025Article
- Genomic Analysis Reveals Racial and Age-Related Differences in the Somatic Landscape of Breast Cancer and the Association with Socioeconomic Factors.Cancer research · 2025Article
- 15-Year Survival Outcome of Primary Breast Conservation Therapy in Young Women with Breast Cancer.Indian journal of surgical oncology · 2025Article
- Challenges in managing recurrent luminal A breast cancer: a case study.Ecancermedicalscience · 2025Article
- A predictive model using MRI and clinicopathologic features for breast cancer recurrence in young women treated with upfront surgery.European radiology · 2024Article
- Risk of first recurrence after treatment in a population-based cohort of young women with breast cancer.Breast cancer research and treatment · 2024Article
- Breast Cancer in Young Women: Is It Different? A Single-Center Retrospective Cohort Study.Clinical Medicine Insights. Oncology · 2024Article
- Determinants of lifestyle and body weight status among breast cancer survivors with overweight/obesity and perspectives towards the development of weight loss interventions: a qualitative study with health professionals from Greece.Journal of nutritional science · 2024Article
- Pattern and risk factors of isolated local relapse among women with hormone receptor-positive and HER2-negative breast cancer and lymph node involvement: 10-year follow-up analysis of the PACS 01 and PACS 04 trials.Breast cancer research and treatment · 2023Article
- CT-derived body composition associated with lung cancer recurrence after surgery.Lung cancer (Amsterdam, Netherlands) · 2023Article
- What Is Known about Breast Cancer in Young Women?Cancers · 2023Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this meta-analysis is to determine the relationship between young age and local recurrence in patients with early-stage breast cancer after breast-conserving therapy. Eligible studies were retrieved from various electronic databases. Among the 19 studies included, 14 studies were analyzed for 5-year local recurrence rate and 8 studies for 10-year local recurrence rate using random effects models. Both results showed that young patients were at higher risk of local recurrence compared to old patients (5-year: RR = 2.64, 95% CI (1.94-3.60); 10-year: RR = 2.37, 95% CI (1.57-3.58)). Harbord's modified test showed the presence of publication bias in both 5- and 10-year local recurrence rates (P = 0.019 and P = 0.01, respectively). While the Trim and Fill analysis showed that the presence of publication bias did not affect the overall outcome of the 5-year local recurrence rate (RR = 2.21, 95% CI (1.62, 3.02)), it significantly affected the effect size of the 10-year local recurrence rate (RR = 1.47, 95% CI (0.96, 2.27)). Young age is a significant risk factor for local recurrence developed within 5 years of breast-conserving therapy in patients with early-stage breast cancer. Further high-quality studies are needed to elucidate the relationship between young age and the risk of local recurrence developed within 10 years.
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