Evidence map›Paper›PMID 28894151›Full record

ArticleScientific reports2017

The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3.

Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Ingrid den Uijl, Ali Bak Al-Hadithi, Samantha C Salvage, Andrew A Grace, Christopher L-H Huang, Kamalan Jeevaratnam

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Brugada Syndrome: Warning of a Systemic Condition?Frontiers in cardiovascular medicine · 2021
    Review
  5. Ageing inBioscience reports · 2019
    Article
  6. Disease Modifiers of InheritedFrontiers in cardiovascular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Karan R ChaddaPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom.
Shiraz AhmadPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom.
Haseeb ValliPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom.
Ingrid den UijlFaculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, United Kingdom.
Ali Bak Al-HadithiPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom.
Samantha C SalvageDepartment of Biochemistry, University of Cambridge, Hopkins Building, Cambridge, CB2 1QW, United Kingdom.ORCID 0000-0002-5793-2349
Andrew A GraceDivision of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Hopkins Building, Cambridge, CB2 1QW, United Kingdom.
Christopher L-H HuangPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom.
Kamalan JeevaratnamFaculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, United Kingdom. drkamalanjeeva@gmail.com.ORCID 0000-0002-6232-388X
University of Cambridge · GBUniversity of Surrey · GB

Funding

British Heart Foundation PG/14/79/31102Medical Research Council MR/M001288/1Wellcome Trust
6 · The paper itself

Abstract

Long QT Syndrome 3 (LQTS3) arises from gain-of-function Na

Indexed as

PhenotypeAdrenergic AgentsAgingAnimalsCardiac Conduction System DiseaseDisease Models, AnimalElectrocardiographyFibrosisHeart Function TestsHumansLong QT SyndromeMiceAdrenergic Agents

Identifiers

PMID28894151
PMCPMC5593918
OpenAlexW2753452788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.