ArticleNature communications2017
A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review.BMC pediatrics · 2020Pooled it
- Azithromycin Exposure Induces Transient Microbial Composition Shifts and Decreases the Airway Microbiota Resilience from Outdoor PMMicrobiology spectrum · 2023Trial
- The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole.PloS one · 2019Trial
- Plasticity of the infant immune system during the perinatal period.Nature reviews. Immunology · 2026Review
- Gut microbiota in health and disease.Molecular biomedicine · 2026Review
- Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice.Nature communications · 2026Article
- Antibiotic-induced gut microbiome dysbiosis: risks and strategies for mitigation.The EMBO journal · 2026Review
- Early supplementation with live combinedFrontiers in cellular and infection microbiology · 2026Observational
- Antagonistic drug interactions protect commensalGut microbes · 2025Article
- Carrot-Derived Nitrogen-Doped Dual-Emission Carbon Dots for Ratiometric Detection of Tetracycline and Oxytetracycline.Journal of fluorescence · 2025Article
- Early Childhood Antibiotics and Chronic Pediatric Conditions: A Retrospective Cohort Study.The Journal of infectious diseases · 2025Article
- IgA Dysfunction Induced by Early-Lifetime Low-Dose Antibiotics Exposure Aggravates Diet-Induced Metabolic Syndrome.Antibiotics (Basel, Switzerland) · 2025Article
- Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age.Mucosal immunology · 2025Review
- Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development.Science (New York, N.Y.) · 2025Article
- The 16p11.2 microdeletion influences how early-life microbiota perturbations affect hippocampal development and behavior throughout the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Integrating network analysis with in vivo-in situ manipulation to elucidate microbiome dynamics in Aedes albopictus.FEMS microbiology letters · 2025Article
- Graphlet-based hyperbolic embeddings capture evolutionary dynamics in genetic networks.Bioinformatics (Oxford, England) · 2024Article
- Alzheimer's Disease Has Its Origins in Early Life via a Perturbed Microbiome.The Journal of infectious diseases · 2024Review
- Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy.bioRxiv : the preprint server for biology · 2024Article
- A Well-Established Gut Microbiota Enhances the Efficiency of Nutrient Metabolism and Improves the Growth Performance ofInternational journal of molecular sciences · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Broad-spectrum antibiotics are frequently prescribed to children. Early childhood represents a dynamic period for the intestinal microbial ecosystem, which is readily shaped by environmental cues; antibiotic-induced disruption of this sensitive community may have long-lasting host consequences. Here we demonstrate that a single pulsed macrolide antibiotic treatment (PAT) course early in life is sufficient to lead to durable alterations to the murine intestinal microbiota, ileal gene expression, specific intestinal T-cell populations, and secretory IgA expression. A PAT-perturbed microbial community is necessary for host effects and sufficient to transfer delayed secretory IgA expression. Additionally, early-life antibiotic exposure has lasting and transferable effects on microbial community network topology. Our results indicate that a single early-life macrolide course can alter the microbiota and modulate host immune phenotypes that persist long after exposure has ceased.High or multiple doses of macrolide antibiotics, when given early in life, can perturb the metabolic and immunological development of lab mice. Here, Ruiz et al. show that even a single macrolide course, given early in life, leads to long-lasting changes in the gut microbiota and immune system of mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.