ArticleScientific reports2017
Mutations in the prostate specific antigen (PSA/KLK3) correlate with male infertility.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Research progress on serine proteases in the field of male reproduction: a narrative review.Translational andrology and urology · 2026Review
- Male infertility and the risk of developing prostate cancer: a bidirectional two-sample Mendelian randomization study.European journal of medical research · 2025Article
- PSA inhibitors for contraception: insights from prostate cancer.Trends in pharmacological sciences · 2025Review
- Androgens modulate endometrial function.Medical molecular morphology · 2025Review
- Exploring the therapeutic effect of melatonin targeting common biomarkers in testicular germ cell tumor, prostate adenocarcinoma, and male infertility: an integrated biology approach.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Comparative functional analyses of the prostate-specific KLK3 enzyme in primates reveal the impact of sexual selection.Evolution; international journal of organic evolution · 2025Article
- Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen.ACS medicinal chemistry letters · 2024Article
- Electrochemical Immunosensor for the Determination of Antibodies against Prostate-Specific Antigen Based on ZnO Nanostructures.International journal of molecular sciences · 2023Article
- Blocking serine protease activity prevents semenogelin degradation leading to hyperviscous semen in humans.Biology of reproduction · 2022Article
- KLK3 in the Regulation of Angiogenesis-Tumorigenic or Not?International journal of molecular sciences · 2021Review
- Review
- Fatherhood status in relation to prostate cancer risks in two large U.S.-based prospective cohort studies.Cancer medicine · 2021Article
- Effect of mild α-chymotrypsin treatment of highly viscous semen samples on fertilization rates.Translational andrology and urology · 2021Article
- Serine protease inhibitor disrupts sperm motility leading to reduced fertility in female mice†.Biology of reproduction · 2020Article
- Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception†.Biology of reproduction · 2020Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate specific antigen (PSA/KLK3) is known to be the chief executor of the fragmentation of semenogelins, dissolution of semen coagulum, thereby releasing sperm for active motility. Recent research has found that semenogelins also play significant roles in sperm fertility by affecting hyaluronidase activity, capacitation and motility, thereby making PSA important for sperm fertility beyond simple semen liquefaction. PSA level in semen has been shown to correlate with sperm motility, suggesting that PSA level/activity can affect fertility. However, no study investigating the genetic variations in the KLK3/PSA gene in male fertility has been undertaken. We analyzed the complete coding region of the KLK3 gene in ethnically matched 875 infertile and 290 fertile men to find if genetic variations in KLK3 correlate with infertility. Interestingly, this study identified 28 substitutions, of which 8 were novel (not available in public databases). Statistical comparison of the genotype frequencies showed that five SNPs, rs266881 (OR = 2.92, P < 0.0001), rs174776 (OR = 1.91, P < 0.0001), rs266875 (OR = 1.44, P = 0.016), rs35192866 (OR = 4.48, P = 0.025) and rs1810020 (OR = 2.08, P = 0.034) correlated with an increased risk of infertility. On the other hand, c.206 + 235 T > C, was more freuqent in the control group, showing protective association. Our findings suggest that polymorphisms in the KLK3 gene correlate with infertility risk.
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