ArticleScientific reports2017
Heightened aversion to risk and loss in depressed patients with a suicide attempt history.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Comparative meta-analysis of task-related functional brain abnormalities in nonsuicidal self-injury and suicide attempt.Frontiers in psychiatry · 2026Pooled it
- Common and Distinct Neural Mechanisms Underlying Risk Seeking and Risk Aversion: Evidence From the Neuroimaging Meta-Analysis.Human brain mapping · 2025Pooled it
- Self-injurious thoughts and behaviors and alterations in positive valence systems: A systematic review of the literature.Journal of psychiatric research · 2022Pooled it
- Clinical Utility of Functional Near-Infrared Spectroscopy for Assessment and Prediction of Suicidality: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- When Losses Matter More: A Dynamic Reference-Dependent Evaluation of Suicide Risk.Risk analysis : an official publication of the Society for Risk Analysis · 2026Article
- Mood computational mechanisms underlying increased risk behavior in adolescent suicidal patients.eLife · 2026Article
- Anterior insula reactivity to loss moderates the association between trait impulsivity and future suicidal ideation in adolescents.Developmental cognitive neuroscience · 2026Article
- Predicting substance use behaviors with machine learning using small sets of judgment and contextual variables.Npj mental health research · 2026Article
- Risk, reward, and suicide: how impulsivity and loss aversion influence decision-making in individuals who have attempted suicide.Frontiers in psychiatry · 2026Article
- Diffusion connectometry reveals white matter substrates of individual differences in loss aversion.Scientific reports · 2025Article
- Exploring Brain Network Dynamics in Suicide Attempt Survivors Using EEG Microstate Analysis.Brain topography · 2025Article
- Exploring risky decision-making dynamics during antidepressant treatment in major depressive disorder: a computational modeling approach.BMC psychiatry · 2025Article
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model.Nature communications · 2025Article
- Changes in the distribution of elements in the liver and various brain regions in suicides from southeastern Poland.Scientific reports · 2025Article
- Neural correlates of decision making and executive function in suicidal thoughts and behaviors.Frontiers in psychiatry · 2025Review
- Acute stress differentially alters reward-related decision making and inhibitory control under threat of punishment.Neurobiology of stress · 2024Review
- Neural responses to decision-making in suicide attempters with youth major depressive disorder.NeuroImage. Clinical · 2024Article
- Decision-Making, Pro-variance Biases and Mood-Related Traits.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Potential neuropsychological mechanism involved in the transition from suicide ideation to action - a resting-state fMRI study implicating the insula.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suicide attempters have been found to be impaired in decision-making; however, their specific biases in evaluating uncertain outcomes remain unclear. Here we tested the hypothesis that suicidal behavior is associated with heightened aversion to risk and loss, which might produce negative predictions about uncertain future events. Forty-five depressed patients with a suicide attempt history, 47 nonsuicidal depressed patients, and 75 healthy controls participated in monetary decision-making tasks assessing risk and loss aversion. Suicide attempters compared with the other groups exhibited greater aversion to both risk and loss during gambles involving potential loss. Risk and loss aversion correlated with each other in the depressed patients, suggesting that a common pathophysiological mechanism underlies these biases. In addition, emotion regulation via suppression, a detrimental emotional control strategy, was positively correlated with loss aversion in the depressed patients, also implicating impairment in regulatory processes. A preliminary fMRI study also found disrupted neural responses to potential gains and losses in the subgenual anterior cingulate cortex, insula cortex, and left amygdala, brain regions involved in valuation, emotion reactivity, and emotion regulation. The findings thus implicate heightened negative valuation in decision-making under risk, and impaired emotion regulation in depressed patients with a history of suicide attempts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.