ArticleNature communications2017
NFATc1 controls the cytotoxicity of CD8
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.
0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed, 197 citations in OpenAlex.
- Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at risk for type 1 diabetes.The Journal of clinical investigation · 2024Trial
- Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients.PloS one · 2018Trial
- Targeting TARDBP to Restore Colonic Barrier Integrity in Ulcerative Colitis via NFATC1 mRNA Destabilization.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis.Signal transduction and targeted therapy · 2026Article
- Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways.Aging cell · 2026Review
- Interleukin 12-tethered nano-aluminum adjuvant orchestrates environmental immunomodulation to empower cytotoxic T cells against solid tumors.Acta pharmaceutica Sinica. B · 2026Article
- Two Faces of NFAT Transcription Factors in LymphocytesBiomolecules · 2026Review
- Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers.Human immunology · 2026Article
- Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications.Science translational medicine · 2026Article
- The significance of immunogenic cell death related prognostic gene markers in colorectal cancer prognosis and antitumor immunity.Scientific reports · 2026Article
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Non-redundant functions of NFATc1 in survival and NFATc2 in generation of exhausted CD8Frontiers in immunology · 2026Article
- Allogeneic haematopoietic cell transplantation promotes atherosclerosis in mice via CD8+ T cells.Cardiovascular research · 2025Article
- Evaluation of dasatinib and ponatinib for the control of CD123 CAR-T cell functionalities.Molecular therapy. Oncology · 2025Article
- JNK knockdown enhances CAR-T cell cytotoxicity through elevated NFATc1-dependent transcription in preclinical ovarian cancer models.Journal for immunotherapy of cancer · 2025Article
- Zeaxanthin augments CD8Cell reports. Medicine · 2025Article
- Glucose-dependent glycosphingolipid biosynthesis fuels CD8Cell metabolism · 2025Article
- Synergistic roles of NFATc1 and c-Jun in immunomodulation.Biochemistry and biophysics reports · 2025Review
- nuTCRacker: Predicting the Recognition of HLA-I-Peptide Complexes by αβTCRs for Unseen Peptides.European journal of immunology · 2025Article
- Systematic characterization of the ovarian landscape across mouse menopause models.bioRxiv : the preprint server for biology · 2025Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 4 institutions in 3 countries.
Stefan Klein-HesslingDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080, Würzburg, Germany.
Khalid MuhammadDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080, Würzburg, Germany.
Matthias KleinInstitute for Immunology, University Medical Center, University of Mainz, D-55131, Mainz, Germany.
Tobias PuschDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080, Würzburg, Germany.
Ronald RudolfDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080, Würzburg, Germany.
Jessica FlöterDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97074, Würzburg, Germany.
Musga QureischiDepartment of Medicine II, Würzburg University Hospital, Research Center for Infectious Diseases, and Interdisciplinary Center for Clinical Science Research, University Würzburg, D-97078, Würzburg, Germany.
Andreas BeilhackDepartment of Medicine II, Würzburg University Hospital, Research Center for Infectious Diseases, and Interdisciplinary Center for Clinical Science Research, University Würzburg, D-97078, Würzburg, Germany.
Martin VaethDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080, Würzburg, Germany.
Carsten KummerowDepartment of Biophysics, CIPMM, Faculty of Medicine, Saarland University, D-66421, Homburg, Germany.ORCID http://orcid.org/0000-0001-5667-2293
Christian BackesDepartment of Biophysics, CIPMM, Faculty of Medicine, Saarland University, D-66421, Homburg, Germany.
Rouven SchoppmeyerDepartment of Biophysics, CIPMM, Faculty of Medicine, Saarland University, D-66421, Homburg, Germany.
Ulrike HahnCellular Neurophysiology, CIPMM, Saarland University, D-66421, Homburg, Germany.
Markus HothDepartment of Biophysics, CIPMM, Faculty of Medicine, Saarland University, D-66421, Homburg, Germany.ORCID http://orcid.org/0000-0001-7080-4643
Tobias BoppInstitute for Immunology, University Medical Center, University of Mainz, D-55131, Mainz, Germany.
Friederike Berberich-SiebeltDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080, Würzburg, Germany.
Amiya PatraDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080, Würzburg, Germany.
Andris AvotsDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080, Würzburg, Germany.
Nora MüllerInstitute for Virology and Immunobiology, University of Würzburg, D-97080, Würzburg, Germany.
Almut SchulzeDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97074, Würzburg, Germany.
Edgar SerflingDepartment of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, D-97080, Würzburg, Germany. serfling.e@mail.uni-wuerzburg.de.
University of Würzburg · DESaarland University · DEJohannes Gutenberg University Mainz · DEUniversitätsklinikum Würzburg · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytotoxic T lymphocytes are effector CD8
Indexed as
AnimalsCD8-Positive T-LymphocytesCytokinesCytoskeletonGene Expression ProfilingGene Expression RegulationGlycolysisGranzymesImmunological SynapsesListeriosisLymphocyte ActivationMiceMice, KnockoutNFATC Transcription FactorsOrganellesT-bet Transcription FactorCytokinesGranzymesGzmb protein, mouseNfatc1 protein, mouseNFATC Transcription FactorsT-bet Transcription FactorT-Box Domain Proteins
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.