ArticleProceedings of the National Academy of Sciences of the United States of America2017
Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling in
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- The control of Plexin A-mediated axon guidance by the Src family kinase Src64B in Drosophila.Genes & genomics · 2026Article
- Direct and transgenerational effects of tetracyclines on the microbiome, transcriptome, and male mating behavior of the sheep blowfly Lucilia cuprina.G3 (Bethesda, Md.) · 2025Article
- The intracellular domain of Sema6A is essential for development of the zebrafish retina.Journal of cell science · 2024Article
- Filamin protects myofibrils from contractile damage through changes in its mechanosensory region.PLoS genetics · 2024Article
- Two distinct mechanisms of Plexin A function in Drosophila optic lobe lamination and morphogenesis.Development (Cambridge, England) · 2024Article
- A protective role for <i>Drosophila</i> Filamin in nephrocytes via Yorkie mediated hypertrophy.Life science alliance · 2022Article
- Molecular Mechanisms Underlying Motor Axon Guidance inMolecules and cells · 2021Review
- Transcriptional Correlates of Chronic Alcohol Neuroadaptation inFrontiers in behavioral neuroscience · 2021Article
- The Fine Art of Writing a Message: RNA Metabolism in the Shaping and Remodeling of the Nervous System.Frontiers in molecular neuroscience · 2021Review
- Identification ofMolecules and cells · 2020Article
- Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.Nature communications · 2019Article
- Midline axon guidance in the Drosophila embryonic central nervous system.Seminars in cell & developmental biology · 2019Review
- Axon formation, extension, and navigation: only a neuroscience phenomenon?Current opinion in neurobiology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The transmembrane semaphorin Sema-1a acts as both a ligand and a receptor to regulate axon-axon repulsion during neural development. Pebble (Pbl), a Rho guanine nucleotide exchange factor, mediates Sema-1a reverse signaling through association with the N-terminal region of the Sema-1a intracellular domain (ICD), resulting in cytoskeletal reorganization. Here, we uncover two additional Sema-1a interacting proteins, varicose (Vari) and cheerio (Cher), each with neuronal functions required for motor axon pathfinding. Vari is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, members of which can serve as scaffolds to organize signaling complexes. Cher is related to actin filament cross-linking proteins that regulate actin cytoskeleton dynamics. The PDZ domain binding motif found in the most C-terminal region of the Sema-1a ICD is necessary for interaction with Vari, but not Cher, indicative of distinct binding modalities. Pbl/Sema-1a-mediated repulsive guidance is potentiated by both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.