ArticleProceedings of the National Academy of Sciences of the United States of America2017
Cortically coordinated NREM thalamocortical oscillations play an essential, instructive role in visual system plasticity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed.
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
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- Sleep and experience-dependent visual plasticity in the adult cerebral cortex: an update.Sleep · 2025Article
- Neurocognition After Perturbed Sleep (NAPS): A Protocol for an Experimental Study Examining the Impact of Sleep on Neurocognition, Functioning, and Clinical Indicators in People with Schizophrenia.medRxiv : the preprint server for health sciences · 2025Article
- A novel mechanism for short-term post-tetanic plasticity in thalamocortical neurons.Brain research · 2025Article
- Article
- Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation.PLoS computational biology · 2025Article
- microRNA-218-5p coordinates scaling of excitatory and inhibitory synapses during homeostatic synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.Sleep · 2025Article
- Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons.bioRxiv : the preprint server for biology · 2025Article
- Rapid and cumulative adult plasticity in the mouse visual cortex.Frontiers in neural circuits · 2025Article
- Stimulus-specific enhancement in mouse visual cortex requires GABA but not VIP-peptide release from VIP interneurons.Journal of neurophysiology · 2024Article
- Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome.Cell reports · 2024Article
- Electrophysiological Signatures of Visual Recognition Memory across All Layers of Mouse V1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Capsaicin Changes the Pattern of Brain Rhythms in Sleeping Rats.Molecules (Basel, Switzerland) · 2023Article
- Functional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation.Nature communications · 2023Article
- Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia.Communications biology · 2023Article
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3 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Two long-standing questions in neuroscience are how sleep promotes brain plasticity and why some forms of plasticity occur preferentially during sleep vs. wake. Establishing causal relationships between specific features of sleep (e.g., network oscillations) and sleep-dependent plasticity has been difficult. Here we demonstrate that presentation of a novel visual stimulus (a single oriented grating) causes immediate, instructive changes in the firing of mouse lateral geniculate nucleus (LGN) neurons, leading to increased firing-rate responses to the presented stimulus orientation (relative to other orientations). However, stimulus presentation alone does not affect primary visual cortex (V1) neurons, which show response changes only after a period of subsequent sleep. During poststimulus nonrapid eye movement (NREM) sleep, LGN neuron overall spike-field coherence (SFC) with V1 delta (0.5-4 Hz) and spindle (7-15 Hz) oscillations increased, with neurons most responsive to the presented stimulus showing greater SFC. To test whether coherent communication between LGN and V1 was essential for cortical plasticity, we first tested the role of layer 6 corticothalamic (CT) V1 neurons in coherent firing within the LGN-V1 network. We found that rhythmic optogenetic activation of CT V1 neurons dramatically induced coherent firing in LGN neurons and, to a lesser extent, in V1 neurons in the other cortical layers. Optogenetic interference with CT feedback to LGN during poststimulus NREM sleep (but not REM or wake) disrupts coherence between LGN and V1 and also blocks sleep-dependent response changes in V1. We conclude that NREM oscillations relay information regarding prior sensory experience between the thalamus and cortex to promote cortical plasticity.
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