Evidence map›Paper›PMID 28893975›Full record

ArticleMolecular pharmacology2017

Agonist-Dependent and -Independent κ Opioid Receptor Phosphorylation: Distinct Phosphorylation Patterns and Different Cellular Outcomes.

Yi-Ting Chiu, Chongguang Chen, Daohai Yu, Stefan Schulz, Lee-Yuan Liu-Chen

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Endothelin-converting enzyme 2 regulates κ opioid receptor trafficking and function.The Journal of pharmacology and experimental therapeutics · 2025
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  10. Strategies for DevelopingThe Journal of pharmacology and experimental therapeutics · 2020
    Review
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  13. The Role of G Protein-coupled Receptor Kinases in Cancer.International journal of biological sciences · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Yi-Ting ChiuCenter for Substance Abuse Research and Department of Pharmacology (Y.-T.C., C.C., L.-Y.L.-C.) and Department of Clinical Sciences (D.Y.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; and Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany (S.S.).
Chongguang ChenCenter for Substance Abuse Research and Department of Pharmacology (Y.-T.C., C.C., L.-Y.L.-C.) and Department of Clinical Sciences (D.Y.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; and Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany (S.S.).
Daohai YuCenter for Substance Abuse Research and Department of Pharmacology (Y.-T.C., C.C., L.-Y.L.-C.) and Department of Clinical Sciences (D.Y.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; and Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany (S.S.).
Stefan SchulzCenter for Substance Abuse Research and Department of Pharmacology (Y.-T.C., C.C., L.-Y.L.-C.) and Department of Clinical Sciences (D.Y.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; and Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany (S.S.).
Lee-Yuan Liu-ChenCenter for Substance Abuse Research and Department of Pharmacology (Y.-T.C., C.C., L.-Y.L.-C.) and Department of Clinical Sciences (D.Y.), Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; and Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany (S.S.) lliuche@temple.edu.
Jena University Hospital · DEFriedrich Schiller University Jena · DETemple University · US

Funding

Pilot Projects Core (PPC)P30DA013429 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI Munir Gunes Kutlu · 2000 to 2026
$34.6M
Mechanism of Action of L THP as an Alternative Therapy for Cocaine AddictionR01AT006899 · NCCIH · MCLEAN HOSPITAL · PI LEE, DAVID YUE-WEI, LIU-CHEN, LEE-YUAN · 2012 to 2016
$2.1M
Generation of knockin mice expressing KOPR conjugated with a fluorescent proteinR03DA036802 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI LIU-CHEN, LEE-YUAN · 2014 to 2015
$154k
NCCIH NIH HHS R01 AT006899NIDA NIH HHS P30 DA013429NIDA NIH HHS R03 DA036802
6 · The paper itself

Abstract

We reported previously that the selective agonist U50,488H promoted phosphorylation of the mouse κ opioid receptor (KOPR) at residues S356, T357, T363, and S369. Here, we found that agonist (U50,488H)-dependent KOPR phosphorylation at all the residues was mediated by Gi/o

Indexed as

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-IsomerAnalgesics, Non-NarcoticAnalgesics, OpioidAnimalsCell Line, TumorDose-Response Relationship, DrugEndocytosisGene Knockdown TechniquesMicePhosphorylationProtein Kinase CReceptors, Opioid, kappa3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-IsomerAnalgesics, Non-NarcoticAnalgesics, OpioidProtein Kinase CReceptors, Opioid, kappa

Identifiers

PMID28893975
PMCPMC5635518
OpenAlexW2953386187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.