Evidence map›Paper›PMID 28893913›Full record

ArticleInfection and immunity2017

Interleukin-17A-Deficient Mice Are Highly Susceptible to Toxoplasma gondii Infection Due to Excessively Induced T. gondii HSP70 and Interferon Gamma Production.

Masataka Moroda, Masaya Takamoto, Yoichiro Iwakura, Jun Nakayama, Fumie Aosai

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Parasitology · 2025
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  3. The Complex Dysregulations of CD4 T Cell Subtypes in HIV Infection.International journal of molecular sciences · 2024
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  4. Effects ofFood and waterborne parasitology · 2023
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  5. Article
  6. Effects of Ovine Monocyte-Derived Macrophage Infection by Recently IsolatedAnimals : an open access journal from MDPI · 2022
    Article
  7. Article
  8. CircRNA and miRNA expression analysis in livers of mice withFrontiers in cellular and infection microbiology · 2022
    Article
  9. Modulation Effects ofVaccines · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans.Biochimica et biophysica acta. Molecular basis of disease · 2020
    Article
  14. Review
  15. A NovelFrontiers in microbiology · 2020
    Article
  16. Strategies Developed byFrontiers in microbiology · 2019
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Masataka MorodaDepartment of Infection and Host Defense, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masaya TakamotoDepartment of Infection and Host Defense, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
Yoichiro IwakuraCenter for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan.
Jun NakayamaDepartment of Molecular Pathology, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
Fumie AosaiDepartment of Infection and Host Defense, Graduate School of Medicine, Chiba University, Chiba, Japan faosai@shinshu-u.ac.jp.
Chiba University · JPShinshu University · JPTokyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin17A (IL-17A) is known to be involved in the host defense against pathogens and the pathogenesis of autoimmune diseases. Previously, we showed that excessive amounts of interferon gamma (IFN-γ) play an important role in the pathogenesis of the lethal effects of

Indexed as

AnimalsAnimal StructuresCD4-Positive T-LymphocytesDisease Models, AnimalHSP70 Heat-Shock ProteinsInterferon-gammaInterleukin-17Mice, Inbred C57BLMice, KnockoutProtozoan ProteinsSurvival AnalysisToxoplasmosis, AnimalHSP70 Heat-Shock ProteinsIl17a protein, mouseInterferon-gammaInterleukin-17Protozoan ProteinsIL-17T. gondii HSP70Toxoplasma gondii

Identifiers

PMID28893913
PMCPMC5695131
OpenAlexW2754666666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.