Evidence map›Paper›PMID 28893910›Full record

ArticleThe Journal of biological chemistry2017

Protonation equilibria and pore-opening structure of the dual-histidine influenza B virus M2 transmembrane proton channel from solid-state NMR.

Jonathan K Williams, Alexander A Shcherbakov, Jun Wang, Mei Hong

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Activation of the influenza B M2 proton channel (BM2).bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Spiers Memorial Lecture: Analysis andFaraday discussions · 2021
    Article
  10. Article
  11. Article
  12. Two-dimensionalJournal of biomolecular NMR · 2020
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Fast Magic-Angle-SpinningThe journal of physical chemistry. B · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jonathan K WilliamsFrom the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and.
Alexander A ShcherbakovFrom the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and.
Jun WangDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721.
Mei HongFrom the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and meihong@mit.edu.ORCID 0000-0001-5255-5858
Massachusetts Institute of Technology · USIIT@MIT · USUniversity of Arizona · US

Funding

Structures and Dynamics of Proton and Cation-Dependent Channels and TransportersR01GM088204 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HONG, MEI · 2009 to 2024
$4.8M
Drug Discovery Targeting the Influenza A Virus M2-S31N Proton ChannelR33AI119187 · NIAID · UNIVERSITY OF ARIZONA · PI PEREZ, DANIEL R, WANG, JUN · 2017 to 2019
$1.2M
NIAID NIH HHS R33 AI119187NIGMS NIH HHS R01 GM088204
6 · The paper itself

Abstract

The influenza A and B viruses are the primary cause of seasonal flu epidemics. Common to both viruses is the M2 protein, a homotetrameric transmembrane proton channel that acidifies the virion after endocytosis. Although influenza A M2 (AM2) and B M2 (BM2) are functional analogs, they have little sequence homology, except for a conserved H

Indexed as

Membranes, ArtificialAmino Acid MotifsInfluenza B virusIon ChannelsNuclear Magnetic Resonance, BiomolecularProtein DomainsViral Matrix ProteinsIon ChannelsMembranes, ArtificialViral Matrix Proteinsinfluenza virusion channelmembrane proteinsolid state NMRstructural biology

Identifiers

PMID28893910
PMCPMC5663885
OpenAlexW2756130782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.