ArticleHypertension (Dallas, Tex. : 1979)2017
Left Ventricular Mass, Brain Magnetic Resonance Imaging, and Cognitive Performance: Results From the Strong Heart Study.
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In one paragraph
Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Left Ventricular Hypertrophy and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of stroke · 2020Pooled it
- Blood pressure, left ventricular structure and cognitive development in young children: a cross-sectional study.World journal of pediatrics : WJP · 2026Article
- Relations of left ventricular mass and hypertrophy to cognitive function in urban dwelling African American and White adults.Neuropsychology · 2026Article
- Genetic insights into the mediating role of cardiac function in hypertension-induced brain cortical changes: a Mendelian randomization study with cardiac magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Cross-Sectional Association Between Left Ventricular Geometric Patterns, Cortical Cerebral Microinfarcts, and Cognition.Journal of the American Heart Association · 2025Article
- Cognitive Outcomes in Young Adults with Primary Arterial Hypertension: The Role of Cardiovascular Risk Factors and Hypertension-Mediated Organ Damage.Medicina (Kaunas, Lithuania) · 2024Article
- Left ventricular hypertrophy as a risk factor for accelerated brain aging: Results from the Study of Health in Pomerania.Human brain mapping · 2024Article
- Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Cognitive Dysfunction in Heart Failure: Pathophysiology and Implications for Patient Management.Current heart failure reports · 2022Review
- The Systemic Effects of Exercise on the Systemic Effects of Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2022Review
- Twenty-Five-Year Change in Cardiac Structure and Function and Midlife Cognition: The CARDIA Study.Neurology · 2022Article
- Axonal Injury Partially Mediates Associations Between Increased Left Ventricular Mass Index and White Matter Damage.Stroke · 2022Observational
- Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population.Journal of the American Heart Association · 2021Article
- Longer Duration of Hypertension and MRI Microvascular Brain Alterations Are Associated with Lower Hippocampal Volumes in Older Individuals with Hypertension.Journal of Alzheimer's disease : JAD · 2020Article
- An Assessment of the Relationship between Structural and Functional Imaging of Cerebrovascular Disease and Cognition-Related Fibers.Computational and mathematical methods in medicine · 2020Article
- Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults.Journal of the American Heart Association · 2018Observational
- Parameters of Left Ventricular Mass and Dementia: Moving the Literature Forward.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Low Hippocampal Dentate Gyrus Volume Associated With Hypertension-Related Cognitive Impairment.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Bernhard HaringDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.). Haring_B@ukw.de.
Adam OmidpanahDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
Astrid M Suchy-DiceyDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
Lyle G BestDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
Steven P VerneyDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
Dean K ShibataDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
Shelley A ColeDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
Tauqeer AliDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
Barbara V HowardDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
Dedra BuchwaldDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
Richard B DevereuxDepartment of Medicine I, Comprehensive Heart Failure Center, University of Würzburg, Bavaria, Germany (B.V.H.); Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (A.O., A.M.S.-D.); Missouri Breaks Industries Research Inc, Eagle Butte, SD (L.G.B.); Department of Psychology and Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque (S.P.V.); Department of Radiology, School of Medicine, University of Washington, Seattle (D.K.S.); Department of Genetics, Texas Biomedical Research Institute, San Antonio (S.A.C.); Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Health Sciences Center (T.A.); MedStar Health Research Institute, Hyattsville, MD (B.V.H.); Initiative for Research and Education to Advance Community Health, Elson S. Floyd College of Medicine, Washington State University, Seattle (D.B.); and Greenberg Division of Cardiology, Weill Cornell Medicine, New York, NY (R.B.D.).
MedStar Health · USMissouri Breaks Industries Research (United States) · USTexas Biomedical Research Institute · USUniversity of New Mexico · USUniversity of Washington · US
Funding
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI BUCHWALD, DEDRA S · 1985 to 2019
$57.2MMaternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8MThe Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2MCARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6MSTRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9MTransdisciplinary Research, Equity and Engagement Center for Advancing Behavioral HealthU54MD004811 · NIMHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CACARI STONE, LISA MARIE · 2017 to 2022
$8.7MCARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9MCerebrovascular Disease and its Consequences in the Strong Study CohortR01HL093086 · NHLBI · WASHINGTON STATE UNIVERSITY · PI BUCHWALD, DEDRA S · 2009 to 2013
$7.3MCVD in American Indians Study and Data Management Center and OK Field CenterR01HL109284 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI STONER, JULIE A · 2013 to 2018
$4.6MCARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IVU01HL065521 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2000 to 2013
$4.3MCVD in American Indians Biomarker lab and Arizona Field CenterR01HL109319 · NHLBI · MEDSTAR HEALTH RESEARCH INSTITUTE · PI UMANS, JASON G · 2013 to 2017
$3.6MCVD in American Indians Genetics CenterR01HL109301 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2013 to 2018
$3.2MNCATS NIH HHS UL1 TR001409NHLBI NIH HHS R01 HL093086NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NIA NIH HHS P50 AG005136NIMHD NIH HHS U54 MD004811
Abstract
Left ventricular mass (LVM) has been shown to serve as a measure of target organ damage resulting from chronic exposure to several risk factors. Data on the association of midlife LVM with later cognitive performance are sparse. We studied 721 adults (mean age 56 years at baseline) enrolled in the Strong Heart Study (SHS, 1993-1995) and the ancillary CDCAI (Cerebrovascular Disease and Its Consequences in American Indians) Study (2010-2013), a study population with high prevalence of cardiovascular disease. LVM was assessed with transthoracic echocardiography at baseline in 1993 to 1995. Cranial magnetic resonance imaging and cognitive testing were undertaken between 2010 and 2013. Generalized estimating equations were used to model associations between LVM and later imaging and cognition outcomes. The mean follow-up period was 17 years. A difference of 25 g in higher LVM was associated with marginally lower hippocampal volume (0.01%; 95% confidence interval, 0.02-0.00;
Indexed as
Cardiovascular DiseasesCognitive DysfunctionHeart VentriclesHypertrophy, Left VentricularBrainCognitionEchocardiographyFemaleHumansIndians, North AmericanIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedOrgan SizePrevalenceblood pressurecognitive functioningechocardiographyleft ventricular massmagnetic resonance imaging
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