ArticleGenetics2017
Will Big Data Close the Missing Heritability Gap?
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fast analysis of biobank-size data and meta-analysis using the BGLR R-package.G3 (Bethesda, Md.) · 2025Pooled it
- Multiple polygenic score approach in colorectal cancer risk prediction.Scientific reports · 2025Article
- Ge-SAND: an explainable deep learning-driven framework for disease risk prediction by uncovering complex genetic interactions in parallel.BMC genomics · 2025Article
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- Biobanks in GENETICS and G3: tackling the statistical challenges.G3 (Bethesda, Md.) · 2025Article
- Polygenic height prediction for the Han Chinese in Taiwan.NPJ genomic medicine · 2025Article
- Mapping the relative accuracy of cross-ancestry prediction.Nature communications · 2024Article
- Bayesian hierarchical hypothesis testing in large-scale genome-wide association analysis.Genetics · 2024Article
- Using residual regressions to quantify and map signal leakage in genomic prediction.Genetics, selection, evolution : GSE · 2023Article
- Biobank-scale methods and projections for sparse polygenic prediction from machine learning.Scientific reports · 2023Article
- Deep integrative models for large-scale human genomics.Nucleic acids research · 2023Article
- Human height: a model common complex trait.Annals of human biology · 2023Review
- The impact of epistasis in the heterosis and combining ability analyses.Frontiers in plant science · 2023Article
- Local genetic covariance between serum urate and kidney function estimated with Bayesian multitrait models.G3 (Bethesda, Md.) · 2022Article
- Explainable deep transfer learning model for disease risk prediction using high-dimensional genomic data.PLoS computational biology · 2022Article
- Mapping pleiotropic loci using a fast-sequential testing algorithm.European journal of human genetics : EJHG · 2021Article
- Multi-generation genomic prediction of maize yield using parametric and non-parametric sparse selection indices.Heredity · 2021Article
- Unlocking big data doubled the accuracy in predicting the grain yield in hybrid wheat.Science advances · 2021Article
- GWAS findings improved genomic prediction accuracy of lipid profile traits: Tehran Cardiometabolic Genetic Study.Scientific reports · 2021Article
- Response to Oxidative Burst-Induced Hypoxia Is Associated With Macrophage Inflammatory Profiles as Revealed by Cellular Genome-Wide Association.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Despite the important discoveries reported by genome-wide association (GWA) studies, for most traits and diseases the prediction R-squared (R-sq.) achieved with genetic scores remains considerably lower than the trait heritability. Modern biobanks will soon deliver unprecedentedly large biomedical data sets: Will the advent of big data close the gap between the trait heritability and the proportion of variance that can be explained by a genomic predictor? We addressed this question using Bayesian methods and a data analysis approach that produces a surface response relating prediction R-sq. with sample size and model complexity (
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Registered trials
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