Evidence map›Paper›PMID 28893793›Full record

ArticleAntimicrobial agents and chemotherapy2017

Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.

Weizhen Xu, Michael A DeJesus, Nadine Rücker, Curtis A Engelhart, Meredith G Wright, Claire Healy, Kan Lin, Ruojun Wang, Sae Woong Park, Thomas R Ioerger and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 124 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Usnic Acid Derivatives as Inhibitors ofInternational journal of molecular sciences · 2026
    Article
  10. Article
  11. An activator of a two-component system controls cell separation and intrinsic drug resistance inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Identifying genetic determinants ofMicrobiology resource announcements · 2025
    Article
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Weizhen XuDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Michael A DeJesusDepartment of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA.
Nadine RückerDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Curtis A EngelhartDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Meredith G WrightDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Claire HealyDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Kan LinDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Ruojun WangDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Sae Woong ParkDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Thomas R IoergerDepartment of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA.
Dirk SchnappingerDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Sabine EhrtDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA sae2004@med.cornell.edu.
Cornell University · USTexas A&M University · US

Funding

Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI AUBE, JEFFREY, GLICKMAN, MICHAEL S · 2014 to 2020
$48.6M
The roles of genes critical for growth under defined conditions in vitro or duriU19AI107774 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CARR, STEVEN A, FORTUNE, SARAH · 2013 to 2017
$13.2M
NIAID NIH HHS U19 AI107774NIAID NIH HHS U19 AI111143
6 · The paper itself

Abstract

Chemotherapy for tuberculosis (TB) is lengthy and could benefit from synergistic adjuvant therapeutics that enhance current and novel drug regimens. To identify genetic determinants of intrinsic antibiotic susceptibility in

Indexed as

Gene Expression Regulation, BacterialAdenosine TriphosphatasesAntitubercular AgentsBacterial ProteinsCell WallDrug Resistance, Multiple, BacterialEthambutolGalactansGene Expression ProfilingHumansIon PumpsIsoniazidLigasesMannosyltransferasesMembrane Transport ProteinsMeropenemAdenosine TriphosphatasesAntitubercular Agentsarabinogalactan-peptidoglycan complexBacterial ProteinsEthambutolGalactansHip1 protein, Mycobacterium tuberculosisIon PumpsIsoniazidLigasesMannosyltransferasesMembrane Transport ProteinsMeropenemMycolic AcidsPeptidoglycanRifampinSecA2 protein, MycobacteriumSerine ProteasesThienamycinsVancomycinantibiotic resistancecell envelopemutational studiesMycobacterium tuberculosis

Identifiers

PMID28893793
PMCPMC5700314
OpenAlexW2754780457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.