Evidence map›Paper›PMID 28893789›Full record

ArticleAntimicrobial agents and chemotherapy2017

Gemini Cationic Amphiphiles Control Biofilm Formation by Bacterial Vaginosis Pathogens.

Ammar Algburi, Yingyue Zhang, Richard Weeks, Nicole Comito, Saskia Zehm, Juanita Pinto, Kathryn E Uhrich, Michael L Chikindas

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Female Vaginal Microbiome in Health and Bacterial Vaginosis.Frontiers in cellular and infection microbiology · 2021
    Review
  7. Bacterial Vaginosis: What Do We Currently Know?Frontiers in cellular and infection microbiology · 2021
    Review
  8. Article
  9. Article
  10. Methicillin-resistantMedChemComm · 2019
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Ammar AlgburiDepartment of Biochemistry and Microbiology, Rutgers State University, New Brunswick, New Jersey, USA.
Yingyue ZhangDepartment of Chemistry and Chemical Biology, Rutgers State University, Piscataway, New Jersey, USA.
Richard WeeksSchool of Environmental and Biological Sciences, Rutgers State University, New Brunswick, New Jersey, USA.
Nicole ComitoDepartment of Biochemistry and Microbiology, Rutgers State University, New Brunswick, New Jersey, USA.
Saskia ZehmDepartment of Life Sciences and Technology, Beuth University of Applied Sciences, Berlin, Germany.
Juanita PintoSchool of Environmental and Biological Sciences, Rutgers State University, New Brunswick, New Jersey, USA.
Kathryn E UhrichDepartment of Chemistry and Chemical Biology, Rutgers State University, Piscataway, New Jersey, USA.
Michael L ChikindasSchool of Environmental and Biological Sciences, Rutgers State University, New Brunswick, New Jersey, USA tchikindas@aesop.rutgers.edu.ORCID 0000-0001-7265-4562
Rutgers, The State University of New Jersey · USBerliner Hochschule für Technik · DE

Funding

Synthetic AMPs that Control Biofilms of Gram-variable PathogensR21AI126053 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI CHIKINDAS, MICHAEL, UHRICH, KATHRYN ELIZABETH · 2016 to 2017
$421k
NIAID NIH HHS R21 AI126053
6 · The paper itself

Abstract

Antibiotic resistance and recurrence of bacterial vaginosis (BV), a polymicrobial infection, justify the need for novel antimicrobials to counteract microbial resistance to conventional antibiotics. Previously, two series of cationic amphiphiles (CAms) which self-assemble into supramolecular nanostructures with membrane-lytic properties were designed with hydrophilic head groups and nonpolar domains. The combination of CAms and commonly prescribed antibiotics is suggested as a promising strategy for targeting microorganisms that are resistant to conventional antibiotics. Activities of the CAms against

Indexed as

Anti-Bacterial AgentsBacterial AdhesionBiofilmsDrug SynergismFemaleGardnerella vaginalisHumansLactiplantibacillus plantarumMetronidazoleMicrobial Sensitivity TestsSurface-Active AgentsVaginaVaginosis, BacterialAnti-Bacterial AgentsMetronidazoleSurface-Active AgentsAMP mimicsantimicrobialsbacterial vaginosisbiofilmGardnerella vaginalis

Identifiers

PMID28893789
PMCPMC5700334
OpenAlexW2754219054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.