ArticleJournal of the American Heart Association2017
Prevalence of Cerebral Microbleeds in Patients With Continuous-Flow Left Ventricular Assist Devices.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Blood stream infection is associated with cerebrovascular accident in patients with left ventricular assist device: a systematic review and meta-analysis.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2018Pooled it
- Repairing the Infarcted Heart: Preclinical Outcomes of Cardiac Tissue Engineering.Stem cell reviews and reports · 2026Review
- Early stroke after left ventricular assist device implantation: role of right heart failure.Journal of thoracic disease · 2023Article
- When Atrial Fibrillation Meets Cerebral Amyloid Angiopathy: Current Evidence and Strategies.Journal of clinical medicine · 2023Review
- Pulsatility and flow patterns across macro- and microcirculatory arteries of continuous-flow left ventricular assist device patients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Neurologic Complications in Patients With Left Ventricular Assist Devices.The Canadian journal of cardiology · 2023Review
- Cerebral Microbleeds During Transcatheter Aortic Valve Replacement: A Prospective Magnetic Resonance Imaging Cohort.Circulation · 2022Observational
- Implications of Causes of Intracranial Hemorrhage During Left Ventricular Assist Device Support.Neurocritical care · 2022Article
- Risk factors of gynecological bleeding in female patients with left-ventricular assist device.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2022Article
- Cerebral Microvascular Injury in Patients with Left Ventricular Assist Device: a Neuropathological Study.Translational stroke research · 2022Article
- A Multi-Domain Simulation Study of a Pulsatile-Flow Pump Device for Heart Failure With Preserved Ejection Fraction.Frontiers in physiology · 2022Article
- Article
- Cerebral Microbleeds and Intracranial Hemorrhages in Adult Patients on Extracorporeal Membrane Oxygenation-Autopsy Study.Critical care explorations · 2021Article
- Ventricular Assist Device-Specific Infections.Journal of clinical medicine · 2021Review
- Bionic women and men - Part 1: Cardiovascular lessons from heart failure patients implanted with left ventricular assist devices.Experimental physiology · 2020Review
- Reduced Activity of von Willebrand Factor after Flow-Diverting Stent Implantation for Intracranial Aneurysms: A Link to Acquired von Willebrand Disease?AJNR. American journal of neuroradiology · 2020Article
- Infective endocarditis of bovine pericardial patch in the aortic position in a patient with left ventricular assist device.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2019Article
- CrossTalk proposal: Blood flow pulsatility in left ventricular assist device patients is essential to maintain normal brain physiology.The Journal of physiology · 2019Article
- Rebuttal from William K. Cornwell III, Takashi Tarumi, Justin Lawley and Amrut V. Ambardekar.The Journal of physiology · 2019Article
- Rebuttal from Eric J. Stöhr, Barry J. McDonnell, Paolo C. Colombo and Joshua Z. Willey.The Journal of physiology · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of cerebral microbleeds (CMBs) in gradient echo T2*-weighted brain MRI has a positive correlation with hemorrhagic stroke incidence. However, the prevalence of CMBs in patients with left ventricular assist devices (LVADs) has not been evaluated. We evaluated the prevalence of CMBs and the relationship with hemorrhagic stroke incidence in patients with LVADs. METHOD AND
resultsWe analyzed results from brain MRI in prospective examinations of 35 consecutive patients who had undergone LVAD explantation for heart transplantation or recovery since 2011. The number and distribution of CMBs were counted, then the relationship between baseline characteristics and adverse events during LVAD support were analyzed. The mean age was 37.7±12.4 years and the mean LVAD duration was 2.43±1.08 years. Thirty-four (97%) patients had at least one CMB. Nine (26%) developed hemorrhagic stroke during LVAD support, and patients with hemorrhagic stroke had a significantly greater number of CMBs compared with patients without hemorrhagic stroke (5 [interquartile range (IQR), 4-7] versus 9 [IQR, 5-23]; odds ratio 1.14 [95% Confidence Interval (CI), 1.02-1.32],
conclusionsThirty-four (97%) patients with continuous-flow LVAD had at least one CMB, and the number of CMBs were more prevalent in patients with hemorrhagic stroke and in patients with LVAD-related infection.
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Registered trials
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