Evidence map›Paper›PMID 28893651›Full record

ArticleNeuroscience2017

Obstructive sleep apnea is associated with altered midbrain chemical concentrations.

Paul M Macey, Manoj K Sarma, Janani P Prasad, Jennifer A Ogren, Ravi Aysola, Ronald M Harper, M Albert Thomas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Paul M MaceySchool of Nursing, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States; Brain Research Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States. Electronic address: pmacey@ucla.edu.
Manoj K SarmaDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States.
Janani P PrasadSchool of Nursing, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States.
Jennifer A OgrenDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States.
Ravi AysolaDepartment of Medicine (Division of Pulmonary and Critical Care), David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States.
Ronald M HarperBrain Research Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States; Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States.
M Albert ThomasDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States.
University of California, Los Angeles · US

Funding

Obstructive Sleep Apnea, Gender Biology, and Autonomic RegulationR01NR013693 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M · 2013 to 2017
$2.0M
Neurochemical Assessment of Sleep Apnea using Accelerated MR Spectroscopic ImagingR56HL131010 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMAS, MICHAEL ALBERT · 2016 to 2016
$648k
NHLBI NIH HHS R56 HL131010NINR NIH HHS R01 NR013693
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is accompanied by altered structure and function in cortical, limbic, brainstem, and cerebellar regions. The midbrain is relatively unexamined, but contains many integrative nuclei which mediate physiological functions that are disrupted in OSA. We therefore assessed the chemistry of the midbrain in OSA in this exploratory study. We used a recently developed accelerated 2D magnetic resonance spectroscopy (2D-MRS) technique, compressed sensing-based 4D echo-planar J-resolved spectroscopic imaging (4D-EP-JRESI), to measure metabolites in the midbrain of 14 OSA (mean age±SD:54.6±10.6years; AHI:35.0±19.4; SAO

Indexed as

AdultAgedEcho-Planar ImagingFemaleHumansMagnetic Resonance SpectroscopyMaleMesencephalonMiddle AgedSleep Apnea, ObstructiveAsc, ascorbateAsp, aspartateautonomicCh, cholineGABA, gamma-aminobutyric acidGln, glutamineGlu, glutamateGly, glycineGPC, glycerophosphorylcholineGSH, glutathioneintermittent hypoxiamagnetic resonance spectroscopymI, myo-inositolNAAG, N-acetylaspartate glutamateNAA, N-acetylaspartatePCh, phosphocholinePE, phosphoethanolamineperiaqueductal grayrespirationScy, scyllo-inositolsleep-disordered breathingTau, taurineThr, threonine

Identifiers

PMID28893651
PMCPMC5983363
OpenAlexW2752471861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.