ArticleNeuroscience2017
Endothelial cells maintain neural stem cells quiescent in their niche.
Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury.Cell communication and signaling : CCS · 2024Article
- Glioma Pericytes Promote Angiogenesis by Producing Periostin.Cellular and molecular neurobiology · 2022Review
- Review
- Circulating Nestin-GFPStem cell reviews and reports · 2021Article
- Hair follicle stem cells as a skin-organizing signaling center during adult homeostasis.The EMBO journal · 2021Review
- Endothelial cell secreted VEGF-C enhances NSC VEGFR3 expression and promotes NSC survival.Stem cell research · 2021Article
- Sensory nerves in the spotlight of the stem cell niche.Stem cells translational medicine · 2021Review
- Single Cell Analysis in Vascular Biology.Frontiers in cardiovascular medicine · 2020Review
- Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone.Scientific reports · 2019Article
- Neural stem cell niche heterogeneity.Seminars in cell & developmental biology · 2019Review
- Staphylococcus epidermidis role in the skin microenvironment.Journal of cellular and molecular medicine · 2019Article
- Article
- Pericyte Plasticity in the Brain.Neuroscience bulletin · 2019Review
- Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression.Cancer metastasis reviews · 2018Review
- Targeting glioblastoma-derived pericytes improves chemotherapeutic outcome.Angiogenesis · 2018Review
- Pericytes Make Spinal Cord Breathless after Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Promyelocytic leukemia protein in mesenchymal stem cells is essential for leukemia progression.Annals of hematology · 2018Review
- Role of Schwann cells in cutaneous wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2018Article
- Perivascular cell αv integrins as a target to treat skeletal muscle fibrosis.The international journal of biochemistry & cell biology · 2018Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Niches are specialized microenvironments that regulate stem cells' activity. The neural stem cell (NSC) niche defines a zone in which NSCs are retained and produce new cells of the nervous system throughout life. Understanding the signaling mechanisms by which the niche controls the NSC fate is crucial for the success of clinical applications. In a recent study, Sato and colleagues, by using state-of-the-art techniques, including sophisticated in vivo lineage-tracing technologies, provide evidence that endothelial amyloid precursor protein (APP) is an important component of the NSC niche. Strikingly, depletion of APP increased NSC proliferation in the subventricular zone, indicating that endothelial cells negatively regulate NSCs' growth. The emerging knowledge from this research will be important for the treatment of several neurological diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.