Evidence map›Paper›PMID 28893599›Full record

ArticleBioorganic & medicinal chemistry2017

Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata.

Huijuan Guo, Maja Rischer, Martin Sperfeld, Christiane Weigel, Klaus Dieter Menzel, Jon Clardy, Christine Beemelmanns

Open access · greenAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  7. Article
  8. The colonial cnidarianEvoDevo · 2020
    Review
  9. Review
  10. Beilstein journal of organic chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Huijuan GuoLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstraβe 11a, D-07745 Jena, Germany.
Maja RischerLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstraβe 11a, D-07745 Jena, Germany.
Martin SperfeldDepartment of Applied and Ecological Microbiology, Institute for Microbiology, Friedrich Schiller University Jena, Philosophenweg 12, D-07743 Jena, Germany.
Christiane WeigelLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstraβe 11a, D-07745 Jena, Germany.
Klaus Dieter MenzelLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstraβe 11a, D-07745 Jena, Germany.
Jon ClardyDepartment of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Harvard University, 240 Longwood Ave., Boston, MA 02115, USA.
Christine BeemelmannsLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstraβe 11a, D-07745 Jena, Germany. Electronic address: Christine.Beemelmanns@hki-jena.de.
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEFriedrich Schiller University Jena · DEHarvard University · US

Funding

Molecule-to-gene approaches to new natural productsR01GM086258 · NIGMS · HARVARD MEDICAL SCHOOL · PI CLARDY, JON · 2008 to 2016
$3.6M
NIGMS NIH HHS R01 GM086258
6 · The paper itself

Abstract

Illumina 16S rRNA gene sequencing was used to profile the associated bacterial community of the marine hydroid Hydractinia echinata, a long-standing model system in developmental biology. 56 associated bacteria were isolated and evaluated for their antimicrobial activity. Three strains were selected for further in-depth chemical analysis leading to the identification of 17 natural products. Several γ-Proteobacteria were found to induce settlement of the motile larvae, but only six isolates induced the metamorphosis to the primary polyp stage within 24h. Our study paves the way to better understand how bacterial partners contribute to protection, homeostasis and propagation of the hydroid polyp.

Indexed as

AnimalsBacteriaBiological ProductsChromatography, High Pressure LiquidGammaproteobacteriaHigh-Throughput Nucleotide SequencingHydrozoaLarvaMass SpectrometryMetamorphosis, BiologicalPhylogenyRNA, Ribosomal, 16SSequence Analysis, DNABiological ProductsRNA, Ribosomal, 16SHydractinia echinataIndolesMetamorphosisSecondary metabolitesSignaling molecules

Identifiers

PMID28893599
PMCPMC5675742
OpenAlexW2733233324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.