ArticleNeuroscience letters2017
Leptin status alters buprenorphine-induced antinociception in obese mice with dysfunctional leptin receptors.
Article in Neuroscience letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state.Frontiers in physiology · 2023Article
- Morphine and high-fat diet differentially alter the gut microbiota composition and metabolic function in lean versus obese mice.ISME communications · 2022Article
- Buprenorphine differentially alters breathing among four congenic mouse lines as a function of dose, sex, and leptin status.Respiratory physiology & neurobiology · 2022Article
- The Relationship of Serum Leptin and Ghrelin Levels with Craving and Withdrawal in Opioid Use Disorder.Alpha psychiatry · 2021Article
- Intranasal Leptin Prevents Opioid-induced Sleep-disordered Breathing in Obese Mice.American journal of respiratory cell and molecular biology · 2020Article
- Article
- Buprenorphine Depresses Respiratory Variability in Obese Mice with Altered Leptin Signaling.Anesthesiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Buprenorphine is an opiate used for pain management and to treat opiate addiction. The cytokine leptin can modulate nociception, but the extent to which buprenorphine-induced antinociception varies as a function of leptin signaling has not been characterized. Four congenic mouse lines with phenotypes that include differences in body weight and leptin status were used to test the hypothesis that the antinociceptive effects of buprenorphine vary as function of sex and leptin signaling. Each mouse line was comprised of males (n=12) and females (n=12) for a total of 96 animals. Groups included C57BL/6J (B6) mice (wild type), B6 mice with diet-induced obesity (DIO), obese B6.Cg-Lep
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.