Evidence map›Paper›PMID 28893516›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2018

Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension.

Kurt W Prins, Stephen L Archer, Marc Pritzker, Lauren Rose, E Kenneth Weir, Alok Sharma, Thenappan Thenappan

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kurt W PrinsCardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Stephen L ArcherDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Marc PritzkerCardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Lauren RoseCardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
E Kenneth WeirCardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Alok SharmaHonorHealth Heart Group, Scottsdale, Arizona, USA.
Thenappan ThenappanCardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota, USA. Electronic address: tthenapp@umn.edu.
University of Minnesota Medical Center · USHonorHealth · USQueen's University · CA

Funding

O2 sensing in the human and rabbit ductus arteriosus.R01HL071115 · NHLBI · UNIVERSITY OF CHICAGO · PI ARCHER, STEPHEN L · 2004 to 2015
$3.1M
The Role of DRP-1 and Mitochondrial Fission in Pulmonary Arterial HypertensionR01HL113003 · NHLBI · QUEEN'S UNIVERSITY AT KINGSTON · PI ARCHER, STEPHEN L · 2013 to 2016
$1.1M
Investigating microtubules in Duchenne cardiomyopathyF32HL129554 · NHLBI · UNIVERSITY OF MINNESOTA · PI PRINS, KURT W · 2015 to 2016
$81k
NHLBI NIH HHS F32 HL129554NHLBI NIH HHS R01 HL071115NHLBI NIH HHS R01 HL113003
6 · The paper itself

Abstract

backgroundAn elevated serum level of interleukin-6 (IL-6) in pulmonary arterial hypertension (PAH) patients results in a greater symptom burden and increased mortality; however, the mechanisms underlying these observations remain unclear. Because both pre-clinical and clinical data associate elevated IL-6 levels with impaired cardiac function, we hypothesized that the adverse effects of IL-6 in PAH result, in part, from right ventricular (RV) dysfunction.

methodsWe analyzed the relationship between IL-6 and RV function in 40 patients with PAH identified in our institutional PAH registry. Serum IL-6 levels was quantified by enzyme-linked immunoassay.

resultsPAH patients had higher IL-6 levels than age- and gender-matched controls. Circulating IL-6 levels correlated inversely with echocardiography-based measures of RV function and RV-pulmonary artery (RV-PA) coupling. When dividing PAH patients by median IL-6 level, patients with higher IL-6 had significantly worse RV function (fractional area change [FAC] 23 ± 12% vs 38 ± 11%, tricuspid annular plane systolic excursion [TAPSE] 1.3 ± 0.3 cm vs 2.1 ± 0.5 cm), impaired RV-PA coupling (0.6 ± 0.5%/mm Hg vs 0.9 ± 0.5%/mm Hg), higher right atrial pressure (13 ± 7 mm Hg vs 9 ± 5 mm Hg), reduced cardiac index (2.0 ± 0.5 liters/min/m

conclusionsSerum IL-6 levels are independently associated with RV function and RV-PA coupling in PAH. Patients with higher IL-6 levels have more severe RV dysfunction and diminished RV-PA coupling despite a comparable severity of pulmonary vascular disease.

Indexed as

Ventricular Function, RightFemaleHumansHypertension, PulmonaryInterleukin-6MaleMiddle AgedVentricular Dysfunction, RightInterleukin-6biomarkersinflammationinterleukinspulmonary hypertensionRV-PA coupling

Identifiers

PMID28893516
PMCPMC5854490
OpenAlexW2753449525

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.