Evidence map›Paper›PMID 28893493›Full record

ArticleSchizophrenia research2018

Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [

Sudhakar Selvaraj, Peter S Bloomfield, Bo Cao, Mattia Veronese, Federico Turkheimer, Oliver D Howes

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PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

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  4. Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Sudhakar SelvarajDepartment of Psychiatry and Behavioural Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA; Psychiatric Imaging Group, MRC Clinical Sciences Centre, Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, W12 0NN, UK. Electronic address: Sudhakar.selvaraj@uth.tmc.edu.
Peter S BloomfieldPsychiatric Imaging Group, MRC Clinical Sciences Centre, Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, W12 0NN, UK.
Bo CaoDepartment of Psychiatry and Behavioural Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA.
Mattia VeroneseCentre for Neuroimaging Sciences, IoPPN, King's College London, Box PO89, De Crespigny Park, London SE5 8AF, UK.
Federico TurkheimerCentre for Neuroimaging Sciences, IoPPN, King's College London, Box PO89, De Crespigny Park, London SE5 8AF, UK.
Oliver D HowesPsychiatric Imaging Group, MRC Clinical Sciences Centre, Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, W12 0NN, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.
Hammersmith Hospital · GBWellcome Centre for Human Neuroimaging · GBKing's College London · GBThe University of Texas Health Science Center at Houston · US

Funding

Medical Research Council G0700995Medical Research Council G0900891Medical Research Council G1100809Medical Research Council MC_U120085814Medical Research Council MC_U120097115Medical Research Council MR/K022733/1Medical Research Council MR/N026063/1Wellcome Trust
6 · The paper itself

Abstract

Patients with schizophrenia show whole brain and cortical gray matter (GM) volume reductions which are progressive early in their illness. Microglia, the resident immune cells in the CNS, phagocytose neurons and synapses. Some post mortem and in vivo studies in schizophrenia show evidence for elevated microglial activation compared to matched controls. However, it is currently unclear how these results relate to changes in cortical structure.

methodsFourteen patients with schizophrenia and 14 ultra high risk for psychosis (UHR) subjects alongside two groups of age and genotype matched healthy controls received [

resultsThe total cortical GM volume was significantly lower in SCZ than the controls [mean (SD)/cm

conclusionsThese findings suggest that microglial activity is related to the altered cortical volume seen in schizophrenia. Longitudinal investigations are required to determine whether microglial activation leads to cortical gray matter loss.

Indexed as

AcetamidesAdolescentAdultBrainCarbon RadioisotopesFemaleGray MatterHumansMagnetic Resonance ImagingMalePositron-Emission TomographyPsychotic DisordersPyridinesReceptors, GABASchizophreniaYoung AdultAcetamidesCarbon RadioisotopesN-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamidePyridinesReceptors, GABATSPO protein, humanBrain volumeGray matterMicrogliaPETPsychosisSchizophrenia

Identifiers

PMID28893493
PMCPMC6027955
OpenAlexW2769429014

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.