ArticleBMC complementary and alternative medicine2017
Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The correlation between traditional Chinese medicine constitution and prediabetes: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Association between Traditional Chinese Medicine constitution and geriatric functional impairment evaluated by the integrated care for older people approach in the elderly.Journal of traditional and complementary medicine · 2026Article
- TCM Constitution and the Risk of Hyperglycemia in Young and Middle-Aged Adults: A Retrospective Cohort Study.Journal of diabetes research · 2026Article
- Personalizing Traditional Chinese Medicine: A Longitudinal Study on How Constitution-Based Configurations Relate to Quality of Life During Comprehensive Intervention.Patient preference and adherence · 2026Article
- Dietary Habits, TCM Constitutions, and Obesity: Investigating the Protective Effects of Vegetarian Dietary Patterns in Taiwan.Healthcare (Basel, Switzerland) · 2025Article
- Harmonizing the mind and body: The interrelationship between traditional Chinese medicine body constitution, mental health and sleep quality.World journal of psychiatry · 2025Article
- Gut microbial characteristics of the damp-heat constitution: a population-based multicenter cross-sectional study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Pharmacological advances in multi-targeted strategies for type 2 diabetes mellitus: a systematic perspective based on traditional Chinese medicine.Frontiers in pharmacology · 2025Review
- Reevaluating Adiponectin's impact on obesity hypertension: a Chinese case-control study.BMC cardiovascular disorders · 2024Article
- Article
- Impact of Different Traditional Chinese Medicine Constitutions on the Clinical Outcomes of COVID-19 Patients Infected with SARS-CoV-2 Omicron Variant: A Retrospective Observational Study.Infection and drug resistance · 2023Article
- Study of Differential Serum Metabolites in Patients with Adenomatous Polyps of Colon and Yang-Deficiency Constitution Based on Ultra-Performance Liquid Chromatography-Mass Spectrometry.Chinese journal of integrative medicine · 2022Article
- Recent evidence in support of traditional chinese medicine to restore normal leptin function in simple obesity.Heliyon · 2022Review
- The Role of Qi-Stagnation Constitution and Emotion Regulation in the Association Between Childhood Maltreatment and Depression in Chinese College Students.Frontiers in psychiatry · 2022Article
- Traditional Chinese Medicine Constitution Is Associated with the Frailty Status of Older Adults: A Cross-Sectional Study in the Community.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The influence of TCM constitutions and neurocognitive function in elderly Macau individuals.Chinese medicine · 2021Article
- Association of Traditional Chinese Medicine Body Constitution and Health-Related Quality of Life in Female Patients with Systemic Lupus Erythematosus: A Cross-Sectional Study.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Effects of Modified Sanzi Yangqin Decoction on Tyrosine Phosphorylation of IRS-1 in Skeletal Muscle of Type 2 Diabetic Rats.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Differential associations of novel metaflammation indices with incident stroke across traditional Chinese medicine constitutions: a retrospective community-based cohort study of older adults.Frontiers in neurologyArticle
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4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) body constitution and serum cytokines, and whether body constitution could independently predict diabetes in IGR subjects.
methodPatients with IGR (n = 306) received a blood test and their body constitution type was assessed using a body constitution questionnaire (BCQ). Serum levels of cytokines were measured by ELISA. Patients were followed up for at least three years, and their status of diabetes were recorded. Multivariate logistic regression was used to estimate odds ratios (ORs) of diabetes for body constitution.
resultsPhlegm-damp, Damp-heat and Qi-deficiency were three most common unbanlenced constitutions among IGR subjects. Phlegm-damp and Damp-heat constitution subjects showed higher serum levels of interleukin 6 (IL-6), tumour necrosis factor-α (TNF-α), leptin and lower serum levels of adiponectin (P<0.05). Qi-deficiency constitution subjects showed higher serum levels of leptin and lower serum levels of adiponectin, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) (P<0.05). Subjects with Phlegm-damp or Damp-heat constitution demonstrated a significantly higher risk of diabetes (P<0.05).
conclusionPhlegm-damp and Damp-heat TCM body constitution are strongly associated with abnormal serum cytokines, and could potentially serve as a predictor of diabetes in IGR subjects. Body constitution can help to identify IGR subjects who are at a high risk of progression to diabetes.
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