ArticleBMC evolutionary biology2017
Conservation and diversification of small RNA pathways within flatworms.
Article in BMC evolutionary biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
- Current and emerging molecular diagnostic approaches in the detection of human parasites.Parasitology research · 2026Review
- Fluke-borne viruses are a risk factor for diseases caused by carcinogenic trematodes.bioRxiv : the preprint server for biology · 2025Article
- Expression of Transposable Elements throughout theNon-coding RNA · 2024Article
- The Evolution and Characterization of the RNA Interference Pathways in Lophotrochozoa.Genome biology and evolution · 2024Article
- Long Non-Coding RNA Levels Are Modulated inNon-coding RNA · 2024Article
- Cell repertoire and proliferation of germinative cells of the model cestodeParasitology · 2022Article
- Cestodes in the genomic era.Parasitology research · 2022Review
- Temperature-induced reorganisation of Schistocephalus solidus (Cestoda) proteome during the transition to the warm-blooded host.Biology open · 2021Article
- Role ofFrontiers in cellular and infection microbiology · 2021Article
- Lost and Found: Piwi and Argonaute Pathways in Flatworms.Frontiers in cellular and infection microbiology · 2021Article
- Long non-coding RNA levels can be modulated by 5-azacytidine in Schistosoma mansoni.Scientific reports · 2020Article
- Long-term experimental evolution reveals purifying selection on piRNA-mediated control of transposable element expression.BMC biology · 2020Article
- Adaptive Radiation of the Flukes of the Family Fasciolidae Inferred from Genome-Wide Comparisons of Key Species.Molecular biology and evolution · 2020Article
- Evidence for densovirus integrations into tapeworm genomes.Parasites & vectors · 2019Article
- Evolutionary Implications of the microRNA- and piRNA Complement ofNon-coding RNA · 2019Article
- The small RNA complement of adult Schistosoma haematobium.PLoS neglected tropical diseases · 2018Article
- Comparative Analysis ofIranian journal of parasitologyArticle
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmall non-coding RNAs, including miRNAs, and gene silencing mediated by RNA interference have been described in free-living and parasitic lineages of flatworms, but only few key factors of the small RNA pathways have been exhaustively investigated in a limited number of species. The availability of flatworm draft genomes and predicted proteomes allowed us to perform an extended survey of the genes involved in small non-coding RNA pathways in this phylum.
resultsOverall, findings show that the small non-coding RNA pathways are conserved in all the analyzed flatworm linages; however notable peculiarities were identified. While Piwi genes are amplified in free-living worms they are completely absent in all parasitic species. Remarkably all flatworms share a specific Argonaute family (FL-Ago) that has been independently amplified in different lineages. Other key factors such as Dicer are also duplicated, with Dicer-2 showing structural differences between trematodes, cestodes and free-living flatworms. Similarly, a very divergent GW182 Argonaute interacting protein was identified in all flatworm linages. Contrasting to this, genes involved in the amplification of the RNAi interfering signal were detected only in the ancestral free living species Macrostomum lignano. We here described all the putative small RNA pathways present in both free living and parasitic flatworm lineages.
conclusionThese findings highlight innovations specifically evolved in platyhelminths presumably associated with novel mechanisms of gene expression regulation mediated by small RNA pathways that differ to what has been classically described in model organisms. Understanding these phylum-specific innovations and the differences between free living and parasitic species might provide clues to adaptations to parasitism, and would be relevant for gene-silencing technology development for parasitic flatworms that infect hundreds of million people worldwide.
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