Evidence map›Paper›PMID 28892884›Full record

ArticleJournal of clinical and diagnostic research : JCDR2017

Effect of Metaboreflex on Cardiovascular System in Subjects of Metabolic Syndrome.

Pramita Dubey, Sunita Tiwari, Manish Bajpai, Kalpana Singh, Praveen Jha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Muscle metaboreflex-induced increases in effective arterial elastance: effect of heart failure.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pramita DubeyJunior Resident, Department of Physiology, KGMU, Lucknow, Uttar Pradesh, India.
Sunita TiwariProfessor and Head, Department of Physiology, KGMU, Lucknow, Uttar Pradesh, India.
Manish BajpaiProfessor, Department of Physiology, KGMU, Lucknow, Uttar Pradesh, India.
Kalpana SinghAssistant Professor, Department of Biochemistry, KGMU, Lucknow, Uttar Pradesh, India.
Praveen JhaSenior Resident, Department of Gastroenterology, RMLIMS, Lucknow, Uttar Pradesh, India.
Government of Uttar Pradesh · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMetaboreflex is a reflex in which muscle receptors send signals regarding metabolic (metabolites accumulation like lactic acid, potassium, adenosine) conditions of the muscles to nucleus tractus solitarius via afferent III and IV fibres to cause haemodynamic adjustments in order to regulate blood flow on the basis of the status of contracting muscle. Dysregulation in its mechanism in metabolic syndrome is demonstrated.

aimTo study the effect of metaboreflex by both isometric and rhythmic handgrip exercise on CVS parameters {Blood Pressure (BP), Cardiac Output (CO) and Systemic Vascular Resistance (SVR)} in subjects of metabolic syndrome. MATERIALS AND

methodsIn this study, 27 subjects aged 25 to 45 years were enrolled after ethical clearance and proper consent. They were divided into: a) subjects without metabolic syndrome; and b) subjects with metabolic syndrome. Impedance cardiovasography was done to assess cardiac parameters (systolic and diastolic blood pressure, cardiac output, systemic vascular resistance). Pre-exercise parameters were assessed followed by isometric exercise and post-isometric exercise parameter measurement. Again after rest, rhythmic exercise was followed. Finally post exercise parameters were assessed. Student paired t-test for comparison between pre and post exercise parameters were done.

resultsChanges in diastolic BP following exercise were statistically significant in subjects without metabolic syndrome (p-value 0.01 and 0.001 following isometric and rhythmic exercise respectively). In subjects with metabolic syndrome also these changes were significant, but to a lesser extent (p-value 0.1 and 0.01 respectively for isometric and rhythmic exercise). Changes in systolic BP following exercise were statistically significant in subjects without metabolic syndrome (p-value 0.001 and 0.001 following isometric and rhythmic exercise respectively). In subjects with metabolic syndrome also these changes were significant (p-value 0.01 and 0.001 respectively for isometric and rhythmic exercise).

conclusionDiminished pressor response is found after exercise in subjects with metabolic syndrome.

Indexed as

Autonomic nervous systemCardiac parametersHaemodynamicsIsometric exerciseRhythmic exercise

Identifiers

PMID28892884
PMCPMC5583908
OpenAlexW2739642765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.