Evidence map›Paper›PMID 28892588›Full record

ArticleAngewandte Chemie (International ed. in English)2017

Remote Loading of Small-Molecule Therapeutics into Cholesterol-Enriched Cell-Membrane-Derived Vesicles.

Xinxin Zhang, Pavimol Angsantikul, Man Ying, Jia Zhuang, Qiangzhe Zhang, Xiaoli Wei, Yao Jiang, Yue Zhang, Diana Dehaini, Mengchun Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
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  6. Bioengineered nanotechnology for nucleic acid delivery.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xinxin ZhangDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Pavimol AngsantikulDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Man YingDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Jia ZhuangDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Qiangzhe ZhangDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Xiaoli WeiDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Yao JiangDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Yue ZhangDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Diana DehainiDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Mengchun ChenDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Yijie ChenDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Weiwei GaoDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Ronnie H FangDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Liangfang ZhangDepartment of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0003-0637-0654

Funding

Tumor-Targeted Chemo-Immunotherapy for Osteosarcoma MetastasisR01CA200574 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LI, SHULIN, ZHANG, LIANGFANG · 2016 to 2020
$1.8M
NCI NIH HHS R01 CA200574
6 · The paper itself

Abstract

The increasing popularity of biomimetic design principles in nanomedicine has led to therapeutic platforms with enhanced performance and biocompatibility. This includes the use of naturally derived cell membranes, which can bestow nanocarriers with cell-specific functionalities. Herein, we report on a strategy enabling efficient encapsulation of drugs via remote loading into membrane vesicles derived from red blood cells. This is accomplished by supplementing the membrane with additional cholesterol, stabilizing the nanostructure and facilitating the retention of a pH gradient. We demonstrate the loading of two model drugs: the chemotherapeutic doxorubicin and the antibiotic vancomycin. The therapeutic implications of these natural, remote-loaded nanoformulations are studied both in vitro and in vivo using animal disease models. Ultimately, this approach could be used to design new biomimetic nanoformulations with higher efficacy and improved safety profiles.

Indexed as

Drug Delivery SystemsNanomedicineAnimalsAnti-Bacterial AgentsAntibiotics, AntineoplasticCell Line, TumorCholesterolDoxorubicinErythrocyte MembraneFemaleHumansHydrogen-Ion ConcentrationMembrane LipidsMiceMice, Inbred BALB CMicroscopy, Electron, TransmissionAnti-Bacterial AgentsAntibiotics, AntineoplasticCholesterolDoxorubicinMembrane LipidsSmall Molecule LibrariesVancomycinbiocompatibilitybiomimetic nanotechnologycell membranedrug deliveryremote loading

Identifiers

PMID28892588
PMCPMC5893863

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.