Evidence map›Paper›PMID 28892470›Full record

ArticleNature immunology2017

Different molecular complexes that mediate transcriptional induction and repression by FoxP3.

Ho-Keun Kwon, Hui-Min Chen, Diane Mathis, Christophe Benoist

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 132 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. FOXP-stabilization of thebioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Effects of CRISPR-Cas9-mediatedMolecular therapy. Methods & clinical development · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. An integrated transcription factor framework for Treg identity and diversity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ho-Keun KwonDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Hui-Min ChenDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Diane MathisDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Christophe BenoistDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0003-1172-6555
Brigham and Women's Hospital · US

Funding

Specification of Treg cells: FOXP3 functional facetsR01AI116834 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2015 to 2019
$2.3M
NIAID NIH HHS R01 AI116834
6 · The paper itself

Abstract

FoxP3 conditions the transcriptional signature and functional facets of regulatory T cells (T

Indexed as

Gene Expression RegulationTranscriptional ActivationAnimalsCells, CulturedDNAForkhead Transcription FactorsGene Expression ProfilingHistone AcetyltransferasesHistone-Lysine N-MethyltransferaseHistone MethyltransferasesImmunoblottingLysine Acetyltransferase 5MiceMice, Inbred C57BLMice, TransgenicMutationDNAForkhead Transcription FactorsFoxp3 protein, mouseHistone AcetyltransferasesHistone-Lysine N-MethyltransferaseHistone MethyltransferasesKat5 protein, mouseLysine Acetyltransferase 5Rela protein, mouseTrans-ActivatorsTranscription Factor RelA

Identifiers

PMID28892470
PMCPMC5679728
OpenAlexW2754312097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.