ArticleNature materials2017
Long-lived force patterns and deformation waves at repulsive epithelial boundaries.
Article in Nature materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations.bioRxiv : the preprint server for biology · 2026Article
- F-actin dynamics regulates collective cell migration by modulating cell shape and stress correlation.Biophysical journal · 2025Article
- Fast yet force-effective mode of supracellular collective cell migration due to extracellular force transmission.PLoS computational biology · 2025Article
- Growing bacterial colonies harness emergent genealogical demixing to regulate organizational entropy.Biophysical reports · 2024Article
- Nucleocytoplasmic transport senses mechanical forces independently of cell density in cell monolayers.Journal of cell science · 2024Article
- Review
- E-cadherin biomaterials reprogram collective cell migration and cell cycling by forcing homeostatic conditions.Cell reports · 2024Article
- [The Dynamic Model of the Active-Inactive Cell Interface].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- ConfluentFUCCI for fully-automated analysis of cell-cycle progression in a highly dense collective of migrating cells.PloS one · 2024Article
- Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD.The Journal of cell biology · 2023Article
- Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology.iScience · 2023Article
- Topological defect-mediated morphodynamics of active-active interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Contribution of mechanical homeostasis to epithelial-mesenchymal transition.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- Pulsations and flows in tissues as two collective dynamics with simple cellular rules.iScience · 2022Article
- Self-assembly of tessellated tissue sheets by expansion and collision.Nature communications · 2022Article
- Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin.Nature aging · 2022Article
- Intercellular water exchanges trigger soliton-like waves in multicellular systems.Biophysical journal · 2022Article
- Collective motility and mechanical waves in cell clusters.The European physical journal. E, Soft matter · 2021Article
- Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers.eLife · 2021Article
- EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts.The Journal of cell biology · 2021Article
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10 authors.
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Abstract
For an organism to develop and maintain homeostasis, cell types with distinct functions must often be separated by physical boundaries. The formation and maintenance of such boundaries are commonly attributed to mechanisms restricted to the cells lining the boundary. Here we show that, besides these local subcellular mechanisms, the formation and maintenance of tissue boundaries involves long-lived, long-ranged mechanical events. Following contact between two epithelial monolayers expressing, respectively, EphB2 and its ligand ephrinB1, both monolayers exhibit oscillatory patterns of traction forces and intercellular stresses that tend to pull cell-matrix adhesions away from the boundary. With time, monolayers jam, accompanied by the emergence of deformation waves that propagate away from the boundary. This phenomenon is not specific to EphB2/ephrinB1 repulsion but is also present during the formation of boundaries with an inert interface and during fusion of homotypic epithelial layers. Our findings thus unveil a global physical mechanism that sustains tissue separation independently of the biochemical and mechanical features of the local tissue boundary.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.