ArticleBrain sciences2017
Vitamin D Receptor Gene Polymorphisms Associated with Childhood Autism.
Article in Brain sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The Association between Vitamin D Status and Autism Spectrum Disorder (ASD): A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- The Correlation Between Vitamin D Receptor (VDR) Gene Polymorphisms and Autism: A Meta-analysis.Journal of molecular neuroscience : MN · 2020Pooled it
- Comprehensive Intervention and Effect of Martial Arts Routines on Children with Autism.Journal of environmental and public health · 2022Trial
- Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer.BioMed research international · 2019Trial
- Vitamin D Receptor rs731236 Polymorphism Modulates Cancer Cachexia Susceptibility and Overall Survival: A Real-World Study on Context-Dependent Vitamin D Signalling.International journal of molecular sciences · 2026Article
- Vitamin D in Autism Spectrum Disorder: A Critical Systematic Review of Evidence and Methodological Limitations.Journal of autism and developmental disorders · 2026Article
- Article
- Sex-Specific effects of vitamin D on autistic behavior and gastrointestinal symptoms in rats via the regulation of serotonin metabolism.Scientific reports · 2025Article
- Impact of gene polymorphisms involved in the vitamin D metabolic pathway on the susceptibility to and severity of autism spectrum disorder.Scientific reports · 2024Article
- Genetic susceptibility of vitamin D receptor gene polymorphisms on autosomal recessive primary microcephaly patients in Pakistani population: a case-control and in-silico study.Molecular biology reports · 2023Article
- Vitamin D receptor gene variants and serum vitamin D in childhood autism spectrum disorder.Molecular biology reports · 2022Article
- Research Progress on the Role of Vitamin D in Autism Spectrum Disorder.Frontiers in behavioral neuroscience · 2022Review
- Vitamin D: A Potential Mitigation Tool for the Endemic Stage of the COVID-19 Pandemic?Frontiers in public health · 2022Review
- Review
- Genetic and molecular biology of autism spectrum disorder among Middle East population: a review.Human genomics · 2021Review
- Novel Probable Glance at Inflammatory Scenario Development in Autistic Pathology.Frontiers in psychiatry · 2021Article
- Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers.International journal of environmental research and public health · 2020Article
- The putative etiology and prevention of autism.Progress in molecular biology and translational science · 2020Review
- Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study.Disease markers · 2020Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorder (ASD) is a group of heterogeneous, behaviorally defined disorders whereby currently no biological markers are common to all affected individuals. A deregulated immune response may be contributing to the etiology of ASD. The active metabolite of vitamin D₃ has an immunoregulatory role mediated by binding to the vitamin D receptor (VDR) in monocyte, macrophages, and lymphocytes. The effects of vitamin D and interaction with the VDR may be influenced by polymorphism in the VDR gene.
methodsGenetic association of four different VDR polymorphisms (Apa-I, Bsm-I, Taq-I, Fok-I) associated with susceptibility to the development of autism in children was investigated.
resultsWe uniquely found an association between the presence of the
conclusionGenetic polymorphism in two SNP in VDR may be correlated with development of ASD symptoms by influencing functionality of vitamin D₃ metabolism, while vitamin D₃ levels were not significantly different between ASD and non-ASD children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.