ArticleAnesthesia and analgesia2018
Delineating the Trajectory of Cognitive Recovery From General Anesthesia in Older Adults: Design and Rationale of the TORIE (Trajectory of Recovery in the Elderly) Project.
Article in Anesthesia and analgesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 16 citations in OpenAlex.
- Trial
- Exploring the Impact of Anesthesia on Postoperative Frailty Trajectories in Older Adults.World journal of surgery · 2026Article
- Association between preoperative sleep disturbance and psychomotor recovery profiles after general anesthesia in day surgery: a prospective cohort study.Scientific reports · 2025Article
- Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population.Scientific reports · 2023Article
- Lateralisation of subcortical functional connectivity during and after general anaesthesia.British journal of anaesthesia · 2022Article
- Goldilocks and propofol dosage in older adults: Too much, too little, or just right?Journal of the American Geriatrics Society · 2021Article
- Resting-state functional connectivity in early postanaesthesia recovery is characterised by globally reduced anticorrelations.British journal of anaesthesia · 2020Article
- Human plasma biomarker responses to inhalational general anaesthesia without surgery.British journal of anaesthesia · 2020Article
- Waking Up to a New Model for Studying Neural Systems: What Emergence from Unconscious States Can Reveal about Brain Organization.Frontiers in systems neuroscience · 2017Article
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13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMechanistic aspects of cognitive recovery after anesthesia and surgery are not yet well characterized, but may be vital to distinguishing the contributions of anesthesia and surgery in cognitive complications common in the elderly such as delirium and postoperative cognitive dysfunction. This article describes the aims and methodological approach to the ongoing study, Trajectory of Recovery in the Elderly (TORIE), which focuses on the trajectory of cognitive recovery from general anesthesia.
methodsThe study design employs cognitive testing coupled with neuroimaging techniques such as functional magnetic resonance imaging, diffusion tensor imaging, and arterial spin labeling to characterize cognitive recovery from anesthesia and its biological correlates. Applying these techniques to a cohort of age-specified healthy volunteers 40-80 years of age, who are exposed to general anesthesia alone, in the absence of surgery, will assess cognitive and functional neural network recovery after anesthesia. Imaging data are acquired before, during, and immediately after anesthesia, as well as 1 and 7 days after. Detailed cognitive data are captured at the same time points as well as 30 days after anesthesia, and brief cognitive assessments are repeated at 6 and 12 months after anesthesia.
resultsThe study is underway. Our primary hypothesis is that older adults may require significantly longer to achieve cognitive recovery, measured by Postoperative Quality of Recovery Scale cognitive domain, than younger adults in the immediate postanesthesia period, but all will fully recover to baseline levels within 30 days of anesthesia exposure. Imaging data will address systems neuroscience correlates of cognitive recovery from general anesthesia.
conclusionsThe data acquired in this project will have both clinical and theoretical relevance regardless of the outcome by delineating the mechanism behind short-term recovery across the adult age lifespan, which will have major implications for our understanding of the effects of anesthetic drugs.
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