Evidence map›Paper›PMID 28891828›Full record

Observational studyAnesthesiology2017

Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients.

Deborah J Culley, Devon Flaherty, Margaret C Fahey, James L Rudolph, Houman Javedan, Chuan-Chin Huang, John Wright, Angela M Bader, Bradley T Hyman, Deborah Blacker and 1 more

2 registry-linked trialsOpen access · greenAbstract readObservational Study
In one paragraph

Observational study in Anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 3 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06326996 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2026Enrolled52ConditionsCoronary Heart Disease, Coronary Artery Bypass GraftingArmsThiamine, Placebo
NCT07760545 recruitingnot on this mapstarted 2023, after this paper: background citation

Reliability In Neurocognitive Telemedicine Screening (RING)

TypeobservationalSponsorUniversity of British ColumbiaRan2023 to 2027Enrolled300ConditionsCognitive Impairment, Preoperative Cognitive Impairment, Perioperative Neurocognitive Disorders, Neurocognitive FunctionArmsModified Mini-Cog Telephone Assessment
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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  12. Perioperative Considerations for Orthopedic Surgery in a Geriatric Population.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2026
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Deborah J CulleyFrom the Harvard Medical School, Boston, Massachusetts (D.J.C., D.F., J.L.R., H.J., A.M.B., B.T.H., D.B., G.C.); Departments of Anesthesiology, Perioperative and Pain Medicine (D.J.C., D.F., M.C.F., C.-C. H., A.M.B., G.C.), Medicine (J.L.R., H.J.), Orthopedic Surgery (J.W.), Brigham and Women's Hospital, Boston, Massachusetts; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts (B.T.H.); Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts (D.B.); and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts (D.B.).
Devon Flaherty
Margaret C Fahey
James L Rudolph
Houman Javedan
Chuan-Chin Huang
John Wright
Angela M Bader
Bradley T Hyman
Deborah Blacker
Gregory Crosby
Brigham and Women's Hospital · US

Funding

THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Preoperative Cognitive Screening in Elderly Surgical Patients: Feasibility and Utility for Predicting MorbidityR21AG048522 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CULLEY, DEBORAH J · 2015 to 2016
$506k
Role of ABeta in neural synapse and circuit remodeling following general anesthesR21AG048637 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CROSBY, GREGORY · 2014 to 2015
$480k
NIA NIH HHS P30 AG062421NIA NIH HHS P50 AG005134NIA NIH HHS R21 AG048522NIA NIH HHS R21 AG048637
6 · The paper itself

Abstract

backgroundThe American College of Surgeons and the American Geriatrics Society have suggested that preoperative cognitive screening should be performed in older surgical patients. We hypothesized that unrecognized cognitive impairment in patients without a history of dementia is a risk factor for development of postoperative complications.

methodsWe enrolled 211 patients 65 yr of age or older without a diagnosis of dementia who were scheduled for an elective hip or knee replacement. Patients were cognitively screened preoperatively using the Mini-Cog and demographic, medical, functional, and emotional/social data were gathered using standard instruments or review of the medical record. Outcomes included discharge to place other than home (primary outcome), delirium, in-hospital medical complications, hospital length-of-stay, 30-day emergency room visits, and mortality. Data were analyzed using univariate and multivariate analyses.

resultsFifty of 211 (24%) patients screened positive for probable cognitive impairment (Mini-Cog less than or equal to 2). On age-adjusted multivariate analysis, patients with a Mini-Cog score less than or equal to 2 were more likely to be discharged to a place other than home (67% vs. 34%; odds ratio = 3.88, 95% CI = 1.58 to 9.55), develop postoperative delirium (21% vs. 7%; odds ratio = 4.52, 95% CI = 1.30 to 15.68), and have a longer hospital length of stay (hazard ratio = 0.63, 95% CI = 0.42 to 0.95) compared to those with a Mini-Cog score greater than 2.

conclusionsMany older elective orthopedic surgical patients have probable cognitive impairment preoperatively. Such impairment is associated with development of delirium postoperatively, a longer hospital stay, and lower likelihood of going home upon hospital discharge.

Indexed as

AgedAged, 80 and overAge FactorsCognition DisordersDeliriumFemaleHumansLength of StayMaleNeuropsychological TestsOrthopedic ProceduresPostoperative ComplicationsPredictive Value of TestsPreoperative CareProspective Studies

Identifiers

PMID28891828
PMCPMC5657553
OpenAlexW2752602132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.