ArticleAlzheimer disease and associated disorders
Factors Influencing Successful Lumbar Puncture in Alzheimer Research.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Hypnosis for pain and anxiety management in cognitively impaired older adults undergoing scheduled lumbar punctures: a randomized controlled pilot study.Alzheimer's research & therapy · 2022Trial
- Protocol to avoid post-dural puncture headache after large-volume cerebral spinal fluid extraction in a prospective observational memory clinic study.Scientific reports · 2025Observational
- Readiness and Barriers to Participate in Alzheimer's and Dementia Research Among Older Adults.Journal of the American Geriatrics Society · 2025Article
- Incidence and Risk Factors of Post-Lumbar Puncture Headache in Patients With Cognitive Impairment.Brain and behavior · 2025Article
- Referral Sources Across Racial and Ethnic Groups at Alzheimer's Disease Research Centers.Journal of Alzheimer's disease : JAD · 2024Article
- Lumbar puncture safety and tolerability in premanifest and manifest Huntington's disease: a multi-analysis cross-sectional study.Scientific reports · 2022Article
- Safety and Feasibility of Research Lumbar Puncture in Huntington's Disease: The HDClarity Cohort and Bioresource.Journal of Huntington's disease · 2022Article
- Development and implementation of an electronic Clinical Dementia Rating and Financial Capacity Instrument-Short Form.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- Detection of β-amyloid positivity in Alzheimer's Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers.Brain communications · 2021Article
- New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer's disease.Experimental & molecular medicine · 2020Review
- Education and Message Framing Increase Willingness to Undergo Research Lumbar Puncture: A Randomized Controlled Trial.Frontiers in medicine · 2020Article
- Factors Associated with Lumbar Puncture Participation in Alzheimer's Disease Research.Journal of Alzheimer's disease : JAD · 2020Observational
- Racial and ethnic differences in older adults' willingness to be contacted about Alzheimer's disease research participation.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Deciphering the factors that influence participation in studies requiring serial lumbar punctures.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI).Parkinsonism & related disorders · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveLumbar puncture (LP) is increasingly common in Alzheimer disease research; however, agreement to undergo LP varies. We sought to determine factors influencing LP consent at Alzheimer's Disease Centers (ADCs) in the United States.
methodsA 3-part survey was distributed to each ADC: (1) ADC LP Experience; (2) LP Requestor Experience; and (3) Patient LP Experience (both Initial and Follow-up). In all, 64 LP Requestor, 579 Patient/Initial, and 404 Patient/Follow-up surveys were collected. Logistic regression analyses with generalized estimating equations were used to assess factors associated with LP agreement and post-LP complications.
resultsAsians and those viewing LP negatively were less likely to agree to LP. Three hundred fifty-two participants had an LP; LP headache occurred in 11.9% (blood patch required in 1.4%) and 9.9% reported other complications. Younger individuals, women, those diagnosed with mild cognitive impairment, use of a Quincke needle, ≤20 mL cerebrospinal fluid drawn, and hemorrhage during LP were associated with LP headache. Use of gravity flow during LP was associated with fewer other complications (nausea, dizziness, vasovagal response, back pain, neck stiffness, and/or nerve root pain).
conclusionsLP in Alzheimer disease research is generally safe and well tolerated. Factors influencing LP agreement potentially could be studied to advance participant acceptance of the procedure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.