Evidence map›Paper›PMID 28891557›Full record

ReviewNature reviews. Immunology2017

Functions of tissue-resident eosinophils.

Peter F Weller, Lisa A Spencer

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04542902 (Non-coding RNAs Analysis of Eosinophil Subtypes in Asthma), which is not on this map. Cited by 271 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
271citing papers in PubMed, 2 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04542902 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Non-coding RNAs Analysis of Eosinophil Subtypes in Asthma

TypeinterventionalSponsorLithuanian University of Health SciencesRan2020 to 2023Enrolled80ConditionsAllergic Asthma, Severe Eosinophilic AsthmaArmsDermatophagoides pteronyssinus allergen, Blood sampling, Bronchial challenge with allergen
3 · Its place in the literature

Who cites it

271 citing papers in PubMed, 2 syntheses or guidelines pooled it, 458 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Tissue adaptation of eosinophils.Journal of leukocyte biology · 2026
    Review
  11. Article
  12. Activation of donor-derived eosinophils during static storage contributes to primary graft dysfunction after lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Eosinophils in solid cancers: sentinels, predictors, and therapeutic allies.Journal of experimental & clinical cancer research : CR · 2026
    Review
  17. Platelet-mast cell dialogue in innate immune response and inflammation.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  18. IL-33 Elicits LTCEuropean journal of immunology · 2026
    Article
  19. Review
  20. Article

211 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peter F WellerDivision of Allergy and Inflammation, Harvard Medical School, Beth Israel Deaconess Medical Center, CLS 943, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
Lisa A SpencerDivision of Allergy and Inflammation, Harvard Medical School, Beth Israel Deaconess Medical Center, CLS 943, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
Beth Israel Deaconess Medical Center · US

Funding

CYTOPLASMIC LIPID BODIES OF INFLAMMATORY CELLSR01AI022571 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLER, PETER F · 1985 to 2013
$4.5M
Human Eosinophils: Mechanisms of FunctioningR37AI020241 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLER, PETER F · 2010 to 2019
$4.5M
HUMAN EOSINOPHILS: MECHANISMS OF FUNCTIONINGR01AI020241 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLER, PETER F · 1985 to 2009
$3.5M
Notch signaling-mediated functions of airway eosinophils in lung diseaseR01HL095699 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SPENCER, LISA ANN · 2010 to 2014
$2.1M
Eosinophil functions in allergic gastrointestinal diseasesR01AI121186 · NIAID · UNIVERSITY OF COLORADO DENVER · PI SPENCER, LISA ANN · 2017 to 2021
$2.0M
NHLBI NIH HHS R01 HL095699NIAID NIH HHS R01 AI020241NIAID NIH HHS R01 AI022571NIAID NIH HHS R01 AI121186NIAID NIH HHS R37 AI020241
6 · The paper itself

Abstract

Eosinophils are a prominent cell type in particular host responses such as the response to helminth infection and allergic disease. Their effector functions have been attributed to their capacity to release cationic proteins stored in cytoplasmic granules by degranulation. However, eosinophils are now being recognized for more varied functions in previously underappreciated diverse tissue sites, based on the ability of eosinophils to release cytokines (often preformed) that mediate a broad range of activities into the local environment. In this Review, we consider evolving insights into the tissue distribution of eosinophils and their functional immunobiology, which enable eosinophils to secrete in a selective manner cytokines and other mediators that have diverse, 'non-effector' functions in health and disease.

Indexed as

AnimalsCell DegranulationCytokinesCytoplasmic GranulesEosinophilsGene Expression RegulationHomeostasisHumansImmunity, InnateInflammation MediatorsOrgan SpecificitySignal TransductionCytokinesInflammation Mediators

Identifiers

PMID28891557
PMCPMC5783317
OpenAlexW2755765772

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.