Evidence map›Paper›PMID 28891434›Full record

ArticleToxicologic pathology2017

Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5.

Vivian S Chen, James P Morrison, Myra F Southwell, Julie F Foley, Brad Bolon, Susan A Elmore

Open access · bronzeAbstract read
In one paragraph

Article in Toxicologic pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 206 citations in OpenAlex.

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  14. Ontogeny of the spinal cord dorsal horn.Science (New York, N.Y.) · 2026
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Vivian S Chen1 Charles River Laboratories Inc., Durham, North Carolina, USA.
James P Morrison2 Charles River Laboratories Inc., Shrewsbury, Massachusetts, USA.
Myra F Southwell3 Cellular Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Julie F Foley4 Bio-Molecular Screening Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Brad Bolon5 GEMpath Inc., Longmont, Colorado, USA.
Susan A Elmore3 Cellular Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Charles River Laboratories (United States) · USNational Institute of Environmental Health Sciences · USNewPath Research · USTriangle · US

Funding

CMPB Pathology Support GroupZICES102505 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HERBERT, RONALD · 2014 to 2021
$67.7M
Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIC ES102505
6 · The paper itself

Abstract

Evaluation of the central nervous system (CNS) in the developing mouse presents unique challenges, given the complexity of ontogenesis, marked structural reorganization over very short distances in 3 dimensions each hour, and numerous developmental events susceptible to genetic and environmental influences. Developmental defects affecting the brain and spinal cord arise frequently both in utero and perinatally as spontaneous events, following teratogen exposure, and as sequelae to induced mutations and thus are a common factor in embryonic and perinatal lethality in many mouse models. Knowledge of normal organ and cellular architecture and differentiation throughout the mouse's life span is crucial to identify and characterize neurodevelopmental lesions. By providing a well-illustrated overview summarizing major events of normal in utero and perinatal mouse CNS development with examples of common developmental abnormalities, this annotated, color atlas can be used to identify normal structure and histology when phenotyping genetically engineered mice and will enhance efforts to describe and interpret brain and spinal cord malformations as causes of mouse embryonic and perinatal lethal phenotypes. The schematics and images in this atlas illustrate major developmental events during gestation from embryonic day (E)7.5 to E18.5 and after birth from postnatal day (P)1 to P21.

Indexed as

Central Nervous SystemAnimalsAtlases as TopicEmbryo, MammalianEmbryonic DevelopmentFemaleFetal DevelopmentGestational AgeHistocytochemistryMicePregnancybrainCNS atlasdevelopmentembryogenetically engineered miceneonatespinal cord

Identifiers

PMID28891434
PMCPMC5754028
OpenAlexW2754348497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.