ArticleThyroid : official journal of the American Thyroid Association2017
Projecting Survival in Papillary Thyroid Cancer: A Comparison of the Seventh and Eighth Editions of the American Joint Commission on Cancer/Union for International Cancer Control Staging Systems in Two Contemporary National Patient Cohorts.
Article in Thyroid : official journal of the American Thyroid Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Optimal extent of thyroidectomy in clinically node-negative unilateral papillary thyroid carcinoma >1 cm and ≤4 cm.Gland surgery · 2026Article
- Utilizing the transformer mechanism to predict cervical lymph node metastasis in patients with papillary thyroid carcinoma.PloS one · 2026Article
- Thyroid Cancer Staging: Historical Evolution and Analysis From Macrocarcinoma to Microcarcinoma.Cureus · 2025Review
- Efficacy of postoperative radioactive iodine therapy for patients with low and intermediate risk papillary thyroid carcinoma.Endocrine · 2025Article
- Tumor-Derived Lactate Drives Malignant Progression of Refractory Papillary Thyroid Carcinoma via the H3K18la-STAT1-LDHA Axis.International journal of biological sciences · 2025Article
- Article
- Disparities in Thyroid Cancer Diagnosis Based on Residence and Distance From Medical Facility.Journal of the Endocrine Society · 2024Article
- Development and validation of survival nomograms for patients with differentiated thyroid cancer with distant metastases: a SEER Program-based study.Journal of endocrinological investigation · 2024Article
- Prognostic impact of lymph node characteristics after therapeutic neck dissection for classic N1 papillary thyroid cancer.BJS open · 2023Article
- Prognostic Utility of Tumor Stage versus American Thyroid Association Risk Class in Thyroid Cancer.The Laryngoscope · 2023Article
- Analysis of risk factors for lateral lymph node metastasis in papillary thyroid carcinoma: A retrospective cohort study.World journal of otorhinolaryngology - head and neck surgery · 2022Article
- Radioiodine remnant ablation in stage I adult papillary thyroid carcinoma: does it improve postoperative outcome?European thyroid journal · 2022Article
- Comparison of the prognostic value of AJCC cancer staging system 7th and 8th editions for differentiated thyroid cancer.BMC endocrine disorders · 2022Article
- Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors.Nature communications · 2022Article
- Clinicopathological and surgical comparisons of differentiated thyroid cancer between China and the USA: A multicentered hospital-based study.Frontiers in public health · 2022Article
- The number of metastatic lymph nodes optimizes staging in patients aged 55 years or older with papillary thyroid cancer.Frontiers in endocrinology · 2022Article
- PSG7 indicates that age at diagnosis is associated with papillary thyroid carcinoma: A study based on the cancer genome atlas data.Frontiers in genetics · 2022Article
- Clinical-Pathological Features and Treatment Outcome of Patients With Hobnail Variant Papillary Thyroid Carcinoma.Frontiers in endocrinology · 2022Article
- Using The Cancer Genome Atlas data to refine the 8th edition of the American Joint Committee on Cancer staging for papillary thyroid carcinoma.Endocrine · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundThis study aims to compare the seventh and eighth editions of the American Joint Commission on Cancer/Union for International Cancer Control (AJCC/UICC) tumor, node, metastasis staging system for patients with papillary thyroid cancer (PTC) in two national patient cohorts.
methodsAdult PTC patients undergoing surgery were selected from the Surveillance, Epidemiology and End Results (SEER) program (2004-2012) and the National Cancer Database (2004-2012). Staging criteria for the seventh and eighth AJCC/UICC editions were applied separately to each cohort. Survival probabilities were estimated using the Kaplan-Meier method. Multivariable Cox proportional hazards models were used to estimate the association of stage with survival in both settings. The Akaike information criterion was used to assess model performance.
resultsAbout 23% of patients were downstaged from the seventh to the eighth edition in SEER, while 24% were downstaged in the National Cancer Database. Disease-specific survival (DSS) and overall survival (OS) were significantly related to stage at diagnosis when using both the seventh and eighth editions of the AJCC/UICC staging system (p < 0.001). Patients classified into higher stages (III and IV) in the eighth edition showed a worse prognosis than those classified into similar stages in the seventh edition. After adjustment, PTC stages as defined by both editions were significantly associated with DSS and OS. With respect to both DSS and OS, the eighth edition PTC model appeared to be a better fit to the data (smaller Akaike information criterion values) compared to the seventh edition.
conclusionBased on these large contemporary national cohorts, the eighth edition AJCC/UICC tumor, node, metastasis classification for PTC is superior to the seventh edition for predicting survival.
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