Evidence map›Paper›PMID 28891198›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2018

Targeted medical nutrition for cachexia in chronic obstructive pulmonary disease: a randomized, controlled trial.

Philip C Calder, Alessandro Laviano, Fredrik Lonnqvist, Maurizio Muscaritoli, Maria Öhlander, Annemie Schols

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 5 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02442908 nacompletednot on this map

A 12-Week, Randomised, Placebo Controlled, Multi-Centre, Parallel Group Study Assessing the Safety and Tolerability of Nutrifriend Cachexia (Non-Complete Dietary Formula) in Patients With Chronic Obstructive Pulmonary Disease (COPD)

TypeinterventionalSponsorSmartfish ASRan2015 to 2016Enrolled45ConditionsCOPD, CachexiaArmsNutrifriend Cachexia, Isocaloric placebo
NCT07288619 nacompletednot on this mapstarted 2025, after this paper: background citation

Evaluation of the Clinical Effectiveness of Nutritional Supplements in Pulmonary Cachexia: A Quasi-Experimental Trial of n-3 PUFAs and Vitamin D

TypeinterventionalSponsorSafeer KhanRan2025 to 2026Enrolled45ConditionsChronic Obstructive Pulmonary Disease (COPD), CachexiaArmsN-3 Polyunsaturated Fatty Acids (PUFA), Vitamin D
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 5 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  15. Medical nutrition therapy in chronic obstructive pulmonary disease: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 5 countries.

Philip C CalderHuman Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Tremona Road, SO16 6YD, Southampton, UK.
Alessandro LavianoDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Fredrik LonnqvistDepartment of Molecular Medicine and Surgery and the Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Maurizio MuscaritoliDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Maria ÖhlanderSmartfish AS, Oslo, Norway.
Annemie ScholsDepartment of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, Netherlands.
Sapienza University of Rome · ITKarolinska Institutet · SEMaastricht University Medical Centre · NLNIHR Southampton Biomedical Research Centre · GBSmartfish (Norway) · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCachectic patients with chronic obstructive pulmonary disease (COPD) may benefit from nutritional support. This double-blind, randomized, controlled trial evaluated the safety and efficacy of targeted medical nutrition (TMN) vs. an isocaloric comparator in pre-cachectic and cachectic patients with COPD.

methodsPatients aged ≥50 years with moderate-to-severe COPD and involuntary weight loss or low body mass index (16-18 kg/m

resultsForty-five patients were randomized to receive TMN (n = 22; mean 69.2 years) or isocaloric comparator (n = 23; mean 69.7 years). TMN was well tolerated. Adverse events were similar in number and type in both groups. Compliance to both products was good (TMN, 79%; comparator, 77%). Both groups gained weight, but the TMN group gained comparatively more fat mass (P = 0.0013). Reductions in systolic blood pressure (P = 0.0418) and secondary endpoints of triglycerides (P = 0.0217) and exercise-induced fatigue (P = 0.0223) and dyspnoea (P = 0.0382), and increases in high-density lipoprotein cholesterol (P = 0.0254), were observed in the TMN vs. the comparator group by week 12.

conclusionsTargeted medical nutrition containing high-dose omega-3 fatty acids, vitamin D, and high-quality protein is well tolerated with a good safety profile and has positive effects on blood pressure and blood lipids and on exercise-induced fatigue and dyspnoea. Therefore, this TMN could be clinically beneficial in the nutritional and metabolic support of pre-cachectic and cachectic patients with COPD.

Indexed as

CachexiaFatty Acids, Omega-3FemaleHumansMaleMiddle AgedNutritional StatusPulmonary Disease, Chronic ObstructiveFatty Acids, Omega-3CachexiaChronic obstructive pulmonary diseaseNutritionOmega-3 fatty acidsPre-cachexia

Identifiers

PMID28891198
PMCPMC5803606
OpenAlexW2751408068

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.