Evidence map›Paper›PMID 28891045›Full record

ArticleThe Journal of comparative neurology2018

A critical period for the trophic actions of leptin on AgRP neurons in the arcuate nucleus of the hypothalamus.

Anna Kamitakahara, Karine Bouyer, Chien-Hua Wang, Richard Simerly

Abstract read
In one paragraph

Article in The Journal of comparative neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 56 citations in OpenAlex.

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  11. AgRP neurons mediate activity-dependent development of oxytocin connectivity and autonomic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Microglia mediate the early-life programming of adult glucose control.bioRxiv : the preprint server for biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anna KamitakaharaThe Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.ORCID http://orcid.org/0000-0001-7213-4145
Karine BouyerThe Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.
Chien-Hua WangThe Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.
Richard SimerlyThe Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.
Children's Hospital of Los Angeles · USUniversity of Southern California · US

Funding

Leptin and Developmental Programming of Hypothalamic Autonomic OutflowR01DK106476 · NIDDK · VANDERBILT UNIVERSITY · PI SIMERLY, RICHARD B · 2016 to 2024
$3.7M
Epigenetic Mechanisms and Developmental Actions of Leptin in the HypothalamusR01DK111831 · NIDDK · VANDERBILT UNIVERSITY · PI SIMERLY, RICHARD B, WATERLAND, ROBERT A · 2017 to 2020
$2.4M
Regulation of Energy Homeostasis by BDNFR01DK089237 · NIDDK · SCRIPPS FLORIDA · PI SIMERLY, RICHARD B, XU, BAOJI · 2011 to 2014
$2.1M
NIDDK NIH HHS R01 DK089237NIDDK NIH HHS R01 DK106476NIDDK NIH HHS R01 DK111831
6 · The paper itself

Abstract

In the developing hypothalamus, the fat-derived hormone leptin stimulates the growth of axons from the arcuate nucleus of the hypothalamus (ARH) to other regions that control energy balance. These projections are significantly reduced in leptin deficient (Lep

Indexed as

Age FactorsAgouti-Related ProteinAnalysis of VarianceAnimalsAnimals, NewbornArcuate Nucleus of HypothalamusAxonsELAV-Like Protein 3Estrogen Receptor alphaFemaleGreen Fluorescent ProteinsIntegrasesLeptinMaleMiceMice, Inbred C57BLAgouti-Related ProteinAgrp protein, mouseCre recombinaseElavl3 protein, mouseELAV-Like Protein 3Estrogen Receptor alphaGreen Fluorescent ProteinsIntegrasesLeptinleptin receptor, mouseNeuropeptide YReceptors, LeptinSTAT3 Transcription Factoragouti-related peptide (AgRP)arcuate nucleus of the hypothalamus (ARH)Critical periodleptinRRID:AB_2313908RRID:IMSR_JAX:000632RRID:IMSR_JAX:006417RRID:IMSR_JAX:007914RRID:SCR_002668sexual dimorphism

Identifiers

PMID28891045
PMCPMC6040218
OpenAlexW2750582226

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.