Evidence map›Paper›PMID 28890844›Full record

ArticleAdvances in biological chemistry2016

Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells In Vitro and in Mice.

Jill A Gadzinski, Jianxia Guo, Brian J Philips, Per Basse, Ethan K Craig, Lisa Bailey, John T Comerci, Julie L Eiseman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Subcutaneous Xenograft Models for Studying PDT In Vivo.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jill A GadzinskiMagee Women's Hospital of the University of Pittsburgh, Department of Obstetrics/Gynecology/Reproductive Sciences, 300 Halket Street, Pittsburgh, USA, 15213.
Jianxia GuoCancer Therapeutics Program, University of Pittsburgh Cancer Institute, and Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 5117 Centre Ave., Pittsburgh, PA 15213.
Brian J PhilipsMagee Women's Hospital of the University of Pittsburgh, Department of Obstetrics/Gynecology/Reproductive Sciences, 300 Halket Street, Pittsburgh, USA, 15213.
Per BasseCancer Immunology Program, University of Pittsburgh Cancer Institute, and Department of Immunology, School of Medicine, University of Pittsburgh, 5117 Centre Ave. Pittsburgh, PA 15213.
Ethan K CraigCancer Therapeutics Program, University of Pittsburgh Cancer Institute, and Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 5117 Centre Ave., Pittsburgh, PA 15213.
Lisa BaileyCancer Immunology Program, University of Pittsburgh Cancer Institute, and Department of Immunology, School of Medicine, University of Pittsburgh, 5117 Centre Ave. Pittsburgh, PA 15213.
John T ComerciMagee Women's Hospital of the University of Pittsburgh, Department of Obstetrics/Gynecology/Reproductive Sciences, 300 Halket Street, Pittsburgh, USA, 15213.
Julie L EisemanCancer Therapeutics Program, University of Pittsburgh Cancer Institute, and Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 5117 Centre Ave., Pittsburgh, PA 15213.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

backgroundCervical cancer is the second most common cancer in women worldwide [1]. Photodynamic therapy has been used for cervical intraepithelial neoplasia with good responses, but few studies have used newer phototherapeutics. We evaluated the effectiveness of photodynamic therapy using Pc 4 in vitro and in vivo against human cervical cancer cells.

methodsCaSki and ME-180 cancer cells were grown as monolayers and spheroids. Cell growth and cytotoxicity were measured using a methylthiazol tetrazolium assay. Pc 4 cellular uptake and intracellular distrubtion were determined. For in vitro Pc 4 photodynamic therapy cells were irradiated at 667nm at a fluence of 2.5 J/cm

resultsThe IC

conclusionsPc 4 photodynamic therapy caused death within cervical cancer cells and xenografts, supporting development of Pc 4 photodynamic therapy for treatment of cervical cancer. Support: P30-CA47904, CTSI BaCCoR Pilot Program.

Indexed as

cervical cancerlasersphotodynamic therapySilicon Phthalocyanine 4

Identifiers

PMID28890844
PMCPMC5589197

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.