ArticleACS catalysis2017
Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid.
Article in ACS catalysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 91 citations in OpenAlex.
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- Uricolysis by Arthrobacter globiformis uricase: structural basis for its catalytic activity and thermostability.Acta pharmacologica Sinica · 2025Article
- Discrimination of first-onset patients with bipolar disorder or major depressive disorder using screened biochemical parameters.Annals of general psychiatry · 2025Article
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- Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity.Nature communications · 2024Article
- Cofactor-independent C-C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis.Beilstein journal of organic chemistry · 2024Article
- Neutron crystallographic refinement with REFMAC5 from the CCP4 suite.Acta crystallographica. Section D, Structural biology · 2023Article
- Spin-Forbidden Addition of Molecular Oxygen to Stable Enol Intermediates-Decarboxylation of 2-Methyl-1-tetralone-2-carboxylic Acid.International journal of molecular sciences · 2023Article
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- Cofactor-free oxidase-mimetic nanomaterials from self-assembled histidine-rich peptides.Nature materials · 2021Article
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- Insights into Ag(i)-catalyzed addition reactions of amino alcohols to electron-deficient olefins: competing mechanisms, role of catalyst, and origin of chemoselectivity.RSC advances · 2018Article
- Catalytic Reaction Mechanism for Drug Metabolism in Human Carboxylesterase-1: Cocaine Hydrolysis Pathway.Molecular pharmaceutics · 2018Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
First-principles quantum mechanical/molecular mechanical (QM/MM)-free energy calculations have been performed to uncover how uricase catalyzes metabolic reactions of uric acid (UA), demonstrating that the entire reaction process of UA in uricase consists of two stages-oxidation followed by hydration. The oxidation consists of four steps: (1) chemical transformation from 8-hydroxyxythine to an anionic radical
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