Evidence map›Paper›PMID 28890812›Full record

ArticleJournal of gastrointestinal oncology2017

Cyclooxygenase-2 gene polymorphisms and susceptibility to colorectal cancer in a Brazilian population.

Michele Tatiana Pereira Tomitão, Sergio Carlos Nahas, Marcia Saldanha Kubrusly, Tatiane Katsue Furuya, Marcio Augusto Diniz, Suely Kazue Nagahashi Marie, Adriana Vaz Safatle-Ribeiro, José Eluf-Neto, Ivan Cecconello, Ulysses Ribeiro Junior

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Michele Tatiana Pereira TomitãoDepartamento de Gastroenterologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brasil.
Sergio Carlos NahasDepartamento de Gastroenterologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brasil.
Marcia Saldanha KubruslyDivisão de Transplante de Órgãos Digestivos LIM 37, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brasil.
Tatiane Katsue FuruyaCentro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, São Paulo/SP, Brasil.
Marcio Augusto DinizCedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA.
Suely Kazue Nagahashi MarieDepartamento de Neurologia LIM 15, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brasil.
Adriana Vaz Safatle-RibeiroDepartamento de Gastroenterologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brasil.
José Eluf-NetoDepartamento de Medicina Preventiva, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brasil.
Ivan CecconelloDepartamento de Gastroenterologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brasil.
Ulysses Ribeiro JuniorDepartamento de Gastroenterologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brasil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRInstituto do Câncer do Estado de São Paulo · BRCedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMulti-ethnicity of Brazilian population displays high levels of genomic diversity. Polymorphism may detect people at higher risk of developing cancer, distinctive response to treatment, and prognosis. Cyclooxygenase-2 (COX-2) is induced in response to growth factors and cytokines, and is expressed in inflammatory diseases, precancerous lesions and colorectal cancer (CRC). The aim of this study was to evaluate the influence of

methodsWe evaluated

resultsPopulations were in Hardy-Weinberg equilibrium (HWE), except for control group of 8473T > C SNP. The frequencies were similar in both groups for genotypes and haplotypes. There was no association between studied polymorphisms and risk of CRC.

conclusionsThe gene polymorphisms studied do not participate in the genetic susceptibility to CRC in a Brazilian population.

Indexed as

colorectal cancer (CRC)cyclooxygenase-2 (COX-2)genesPolymorphismrisksingle nucleotide polymorphism (SNP)susceptibility

Identifiers

PMID28890812
PMCPMC5582032
OpenAlexW2600139594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.