Evidence map›Paper›PMID 28890682›Full record

ArticleFrontiers in neuroscience2017

Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice.

Robert S Rogers, Sudheer Tungtur, Tomohiro Tanaka, Lisa L Nadeau, Yomna Badawi, Hua Wang, Hong-Min Ni, Wen-Xing Ding, Hiroshi Nishimune

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The Neuromuscular Junction: A Shared Vulnerability in Aging and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Targeting mitophagy in neurodegenerative diseases.Nature reviews. Drug discovery · 2025
    Review
  12. Article
  13. Review
  14. Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases?BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Robert S RogersDepartment of Anatomy and Cell Biology, University of Kansas School of MedicineKansas City, KS, United States.
Sudheer TungturDepartment of Anatomy and Cell Biology, University of Kansas School of MedicineKansas City, KS, United States.
Tomohiro TanakaDepartment of Anatomy and Cell Biology, University of Kansas School of MedicineKansas City, KS, United States.
Lisa L NadeauDepartment of Anatomy and Cell Biology, University of Kansas School of MedicineKansas City, KS, United States.
Yomna BadawiDepartment of Anatomy and Cell Biology, University of Kansas School of MedicineKansas City, KS, United States.
Hua WangDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas School of MedicineKansas City, KS, United States.
Hong-Min NiDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas School of MedicineKansas City, KS, United States.
Wen-Xing DingDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas School of MedicineKansas City, KS, United States.
Hiroshi NishimuneDepartment of Anatomy and Cell Biology, University of Kansas School of MedicineKansas City, KS, United States.
University of Kansas · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
UNDERSTANDING THE ROLE OF SMALL RNAS IN ARABIDOPSIS POLLEN DEVELOPMENTP20RR016475 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ACKLEY, BRIAN DOUGLAS · 2001 to 2011
$38.1M
Transgenic and Gener-Targeting CoreP20GM104936 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN · 2012 to 2016
$10.9M
U KANSAS COBRE ADMINISTRATIVE COREP20RR024214 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KRIEG, ADAM J · 2007 to 2011
$10.8M
Molecular Regulation of Cell Development and Differentiation Phase III COBREP30GM122731 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VIVIAN, JAY L · 2017 to 2021
$5.6M
Mechanisms regulating autophagy in alcohol-induced liver injuryR01AA020518 · NIAAA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DING, WEN-XING · 2011 to 2018
$2.3M
Exercise-activated mechanisms reduce degeneration of aged neuromuscular junctionsR01AG051470 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MERINEY, STEPHEN D, NISHIMUNE, HIROSHI · 2015 to 2019
$1.9M
Active zone loss cause dying back neuropathy in amyotrophic lateral sclerosisR01NS078214 · NINDS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NISHIMUNE, HIROSHI · 2012 to 2016
$1.6M
NCRR NIH HHS P20 RR016475NCRR NIH HHS P20 RR024214NIAAA NIH HHS R01 AA020518NIA NIH HHS R01 AG051470NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM104936NIGMS NIH HHS P30 GM122731NINDS NIH HHS R01 NS078214
6 · The paper itself

Abstract

Motor neurons in amyotrophic lateral sclerosis (ALS) patients and animal models show degeneration from the nerve terminal, known as dying-back neuropathy. To investigate the mechanism underlying this neuropathy, we analyzed the neuromuscular junctions (NMJs) and motor neuron cell bodies in SOD1

Indexed as

ALSautophagydenervationmitophagyNMJp62/SQSTM1SOD1G93A mice

Identifiers

PMID28890682
PMCPMC5575151
OpenAlexW2749427944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.