Evidence map›Paper›PMID 28890584›Full record

ArticleJournal of the American Statistical Association2017

Interactive Q-learning for Quantiles.

Kristin A Linn, Eric B Laber, Leonard A Stefanski

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Variable selection for individualised treatment rules with discrete outcomes.Journal of the Royal Statistical Society. Series C, Applied statistics · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Performance Guarantees for Policy Learning.Annales de l'I.H.P. Probabilites et statistiques · 2020
    Article
  7. Estimating Dynamic Treatment Regimes in Mobile Health Using V-learning.Journal of the American Statistical Association · 2020
    Article
  8. Article
  9. Precision Medicine.Annual review of statistics and its application · 2019
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristin A LinnDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104.
Eric B LaberDepartment of Statistics, North Carolina State University, Raleigh, NC 27695.
Leonard A StefanskiDepartment of Statistics, North Carolina State University, Raleigh, NC 27695.

Funding

Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TSIATIS, ANASTASIOS A · 2010 to 2019
$21.3M
Flexible Statistical Methods for Biomedical DataR01CA085848 · NCI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DAVIDIAN, MARIE · 2000 to 2015
$3.1M
National Science Foundation DMS-0906421National Science Foundation DMS-1406456NCI NIH HHS P01 CA142538NCI NIH HHS R01 CA085848
6 · The paper itself

Abstract

A dynamic treatment regime is a sequence of decision rules, each of which recommends treatment based on features of patient medical history such as past treatments and outcomes. Existing methods for estimating optimal dynamic treatment regimes from data optimize the mean of a response variable. However, the mean may not always be the most appropriate summary of performance. We derive estimators of decision rules for optimizing probabilities and quantiles computed with respect to the response distribution for two-stage, binary treatment settings. This enables estimation of dynamic treatment regimes that optimize the cumulative distribution function of the response at a prespecified point or a prespecified quantile of the response distribution such as the median. The proposed methods perform favorably in simulation experiments. We illustrate our approach with data from a sequentially randomized trial where the primary outcome is remission of depression symptoms.

Indexed as

Dynamic Treatment RegimePersonalized MedicineSequential Decision MakingSequential Multiple Assignment Randomized Trial

Identifiers

PMID28890584
PMCPMC5586239

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.