Evidence map›Paper›PMID 28890536›Full record

ArticleImmunology and cell biology2017

A key role for IL-7R in the generation of microenvironments required for thymic dendritic cells.

Amanda J Moore, Tracy Sh In, Ashton Trotman-Grant, Kogulan Yoganathan, Bertrand Montpellier, Cynthia J Guidos, Juan Carlos Zúñiga-Pflücker, Michele K Anderson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology and cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Thymus Degeneration and Regeneration.Frontiers in immunology · 2021
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Amanda J MooreBiological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Tracy Sh InBiological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Ashton Trotman-GrantBiological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Kogulan YoganathanBiological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Bertrand MontpellierDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Cynthia J GuidosDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-7674-2612
Juan Carlos Zúñiga-PflückerBiological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0003-2538-3178
Michele K AndersonBiological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0002-8820-5910
Sunnybrook Health Science Centre · CAUniversity of Toronto · CA

Funding

The role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI CORNELIS MURRE · 2014 to 2026
$26.3M
CIHR MOP11530CIHR MOP 119538CIHR MOP 82861NIAID NIH HHS P01 AI102853
6 · The paper itself

Abstract

Interleukin-7 receptor (IL-7R) signaling is critical for multiple stages of T-cell development, but a role in the establishment of the mature thymic architecture needed for T-cell development and thymocyte selection has not been established. Crosstalk signals between developing thymocytes and thymic epithelial cell (TEC) precursors are critical for their differentiation into cortical TECs (cTECs) and medullary TECs (mTECs). In addition, mTEC-derived factors have been implicated in the recruitment of thymic dendritic cells (DCs) and intrathymic DC development. We therefore examined corticomedullary structure and DC populations in the thymus of Il7r

Indexed as

AnimalsCell DifferentiationCells, CulturedCellular MicroenvironmentChemokine CXCL12Chemokines, CCDendritic CellsEpithelial CellsMiceMice, Inbred C57BLMice, KnockoutReceptors, CCR7Receptors, Interleukin-7Thymus GlandT-LymphocytesCcl25 protein, mouseCcr7 protein, mouseChemokine CXCL12Chemokines, CCReceptors, CCR7Receptors, Interleukin-7

Identifiers

PMID28890536
PMCPMC5698111
OpenAlexW2754472161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.