ArticleStructure (London, England : 1993)2017
Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA.
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Article in Structure (London, England : 1993), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- Molecular Dynamics of PPAR Nuclear Receptors: From Ligand Binding to Transcriptional Regulation.Cells · 2026Review
- Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers.eLife · 2026Article
- DNA induces non-canonical dimerization of the farnesoid X receptor.Nucleic acids research · 2026Article
- New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators.Nucleic acids research · 2025Article
- Agonists of the Nuclear Receptor PPARγ Can Produce Biased Signaling.Molecular pharmacology · 2024Article
- New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1.ACS chemical biology · 2023Article
- Structural insights into the HNF4 biology.Frontiers in endocrinology · 2023Review
- A structural mechanism of nuclear receptor biased agonism.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Microsecond MD Simulations to Explore the Structural and Energetic Differences between the Human RXRα-PPARγ vs. RXRα-PPARγ-DNA.Molecules (Basel, Switzerland) · 2022Article
- Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems.Chemical reviews · 2022Review
- Cooperativity as quantification and optimization paradigm for nuclear receptor modulators.Chemical science · 2022Article
- Remembering your A, B, C's: Alzheimer's disease and ABCA1.Acta pharmaceutica Sinica. B · 2022Review
- Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement.Journal of molecular biology · 2021Article
- Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARα.International journal of molecular sciences · 2021Review
- Evolution of Hominin Detoxification: Neanderthal and Modern Human Ah Receptor Respond Similarly to TCDD.Molecular biology and evolution · 2021Article
- The diversity of molecular interactions involving intrinsically disordered proteins: A molecular modeling perspective.Computational and structural biotechnology journal · 2021Review
- Hydrogen-Deuterium Exchange Mass Spectrometry: A Novel Structural Biology Approach to Structure, Dynamics and Interactions of Proteins and Their Complexes.Life (Basel, Switzerland) · 2020Review
- Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer.Nucleic acids research · 2020Article
- Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR.Nucleic acids research · 2020Article
- PPARInternational journal of nephrology · 2020Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Ian Mitchelle S de VeraDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Jie ZhengDepartment of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Scott NovickDepartment of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Jinsai ShangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Travis S HughesDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Richard BrustDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Paola Munoz-TelloDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
William J GardnerDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; TSRI High School Student Summer Internship Program, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
David P MarcianoDepartment of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Xiangming KongDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Patrick R GriffinDepartment of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Douglas J KojetinDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA. Electronic address: dkojetin@scripps.edu.
Scripps Research Institute · US
Funding
Molecular Characterization of Novel Insulin SensitizersR01DK105825 · NIDDK · SCRIPPS FLORIDA · PI GRIFFIN, PATRICK ROBERT · 2015 to 2019
$2.9MStructure and Function of Alternate-Site Binding of Anti-Diabetic PPARG LigandsR01DK101871 · NIDDK · SCRIPPS FLORIDA · PI KOJETIN, DOUGLAS · 2014 to 2018
$2.1MStructural mechanism and function of endogenous ligands targeting orphan NR4A receptorsR01GM114420 · NIGMS · SCRIPPS FLORIDA · PI KOJETIN, DOUGLAS · 2015 to 2018
$1.5MConnecting the functional effects of drugs to how they change PPAR gammaR00DK103116 · NIDDK · UNIVERSITY OF MONTANA · PI HUGHES, TRAVIS SHANE · 2016 to 2018
$727kStructural Analysis of Corepressor Binding to PPARγF32DK108442 · NIDDK · SCRIPPS FLORIDA · PI BRUST, RICHARD JAMES · 2016 to 2018
$178kConnecting the functional effects of drugs to how they change PPAR gammaK99DK103116 · NIDDK · SCRIPPS FLORIDA · PI HUGHES, TRAVIS SHANE · 2014 to 2015
$178kLinking partial and non-agonist induced dynamics to PPAR gamma functionsF32DK097890 · NIDDK · SCRIPPS FLORIDA · PI HUGHES, TRAVIS SHANE · 2012 to 2013
$110kNIDDK NIH HHS F32 DK097890NIDDK NIH HHS F32 DK108442NIDDK NIH HHS K99 DK103116NIDDK NIH HHS R00 DK103116NIDDK NIH HHS R01 DK101871NIDDK NIH HHS R01 DK105825NIGMS NIH HHS R01 GM114420
Abstract
Nuclear receptor (NR) transcription factors bind various coreceptors, small-molecule ligands, DNA response element sequences, and transcriptional coregulator proteins to affect gene transcription. Small-molecule ligands and DNA are known to influence receptor structure, coregulator protein interaction, and function; however, little is known on the mechanism of synergy between ligand and DNA. Using quantitative biochemical, biophysical, and solution structural methods, including
Indexed as
Binding SitesCarbon-13 Magnetic Resonance SpectroscopyDeuterium Exchange MeasurementDNAGene Expression RegulationHumansLigandsMultiprotein ComplexesNuclear Receptor Coactivator 2PPAR gammaProtein BindingRetinoid X Receptor alphaDNALigandsMultiprotein ComplexesNCOA2 protein, humanNuclear Receptor Coactivator 2PPAR gammaRetinoid X Receptor alphaallosterycooperativityhydrogen/deuterium exchange (HDX) mass spectrometryligand bindingNMR spectroscopynuclear receptorperoxisome proliferator-activated receptorretinoid X receptorstabilizationtranscription
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.