ArticlePsychiatry research2017
Early life stress predicts negative urgency through brooding, depending on 5-HTTLPR genotype: A pilot study with 6-month follow-up examining suicide ideation.
Article in Psychiatry research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Association between 5-HT1A receptor C-1019G, 5-HTTLPR polymorphisms and panic disorder: a meta-analysis.Aging · 2024Pooled it
- Explaining the Link Between PTSD and Suicide: A Meta-Analysis to Introduce the CEASE Framework.Psychological reports · 2026Article
- Perceived stress and compulsive buying among Saudi adults: the mediation role of rumination.BMC psychology · 2025Article
- Molecular Effect of Variants in Serotonin Transporter Gene in Women with Alcohol Use Disorder.Cells · 2025Article
- The Effect of Depression and Hopelessness on Suicidal Risk in Young People: The Mediating Role of Impulsivity.Clinical psychology in Europe · 2025Article
- Circuitry correlates of negative urgency and suicidality in schizophrenia spectrum disorders: a LASSO regression study.Frontiers in psychiatry · 2025Article
- The role of parental maladaptive emotion socialization in the risk process for negative urgency and drinking behavior in adolescence.Journal of adolescence · 2024Article
- Social cognitive mechanisms between psychological maltreatment and adolescent suicide ideation: Race/ethnicity and gender as moderators.Psychology of violence · 2022Article
- Emotion-related impulsivity and rumination: Unique and conjoint effects on suicidal ideation, suicide attempts, and nonsuicidal self-injury across two samples.Suicide & life-threatening behavior · 2022Article
- Impulsive reactivity to emotion and vulnerability to psychopathology.The American psychologist · 2018Review
- Understanding the social context of adolescent nonsuicidal self-injury.Journal of clinical psychology · 2018Article
- Early Life Trauma, Suicide Ideation, and Suicide Attempts: The Role of Rumination and Impulsivity.Archives of suicide research : official journal of the International Academy for Suicide ResearchArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
The present study examined the interaction between early life stress and 5-HTT genotypes in predicting two risk factors for suicidal behavior - the brooding subtype of rumination and impulsivity, in the form of negative urgency - over time. Furthermore, we examined early life stress, brooding, and impulsivity as predictors of suicidal ideation over time. Participants with and without a history of early life stress were genotyped for the 5-HTTLPR polymorphism and completed assessments assessing brooding and negative urgency at baseline and 6-month follow up. Early life emotional abuse was associated with negative urgency at follow-up. We found an indirect effect of early life emotional abuse on negative urgency through brooding among individuals with 5-HTT low expressing genotypes but not among individuals with 5-HTT high expressing genotypes. Further, a logistic regression analysis revealed that negative urgency was associated with higher odds (O.R. = 16.2) of reporting suicide ideation (versus no ideation) at follow-up. Our findings suggest that brooding and negative urgency may result from the interaction between early life emotional abuse and 5-HTT low expressing genotypes. Further research is necessary to understand how early life stress interacts with 5-HTT genotypes to confer risk for suicidal behavior through psychological mechanisms.
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