ArticleStem cell reports2017
Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles.
Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- TRF2 couples muscle stem cell identity to regenerative repair.Science advances · 2026Article
- Nuclear Lamina Dysfunction and DNA Damage as Drivers of Premature Senescence in a Human Müller Glial Cell Model of Spinocerebellar Ataxia Type 7.International journal of molecular sciences · 2026Article
- Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells.Stem cell reports · 2025Article
- Epigenetic control of myogenic identity of human muscle stem cells in Duchenne muscular dystrophy.iScience · 2024Article
- 3D Super-Resolution Nuclear Q-FISH Imaging Reveals Cell-Cycle-Related Telomere Changes.International journal of molecular sciences · 2024Article
- Molecular and Structural Alterations of Skeletal Muscle Tissue Nuclei during Aging.International journal of molecular sciences · 2024Review
- Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length.NPJ microgravity · 2023Article
- Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro-adipogenic progenitors.EMBO reports · 2022Article
- Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states.Science advances · 2022Article
- Genetic and Epigenetic Inheritance at Telomeres.Epigenomes · 2022Review
- Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections.STAR protocols · 2021Article
- Gli1 Defines a Subset of Fibro-adipogenic Progenitors that Promote Skeletal Muscle Regeneration With Less Fat Accumulation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening.Cell reports · 2021Article
- The Duchenne muscular dystrophy gene and cancer.Cellular oncology (Dordrecht, Netherlands) · 2021Review
- From Development to Aging: The Path to Cellular Senescence.Antioxidants & redox signaling · 2021Review
- Airway Epithelial Telomere Dysfunction Drives Remodeling Similar to Chronic Lung Allograft Dysfunction.American journal of respiratory cell and molecular biology · 2020Article
- Extra-telomeric impact of telomeres: Emerging molecular connections in pluripotency or stemness.The Journal of biological chemistry · 2020Review
- Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability.International journal of molecular sciences · 2020Article
- Pathobiology of frailty in lung disease.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Effect of exercise on telomere length and telomere proteins expression in mdx mice.Molecular and cellular biochemistry · 2020Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
Muscle stem cells (MuSCs) contribute to muscle regeneration following injury. In many muscle disorders, the repeated cycles of damage and repair lead to stem cell dysfunction. While telomere attrition may contribute to aberrant stem cell functions, methods to accurately measure telomere length in stem cells from skeletal muscles have not been demonstrated. Here, we have optimized and validated such a method, named MuQ-FISH, for analyzing telomere length in MuSCs from either mice or humans. Our analysis showed no differences in telomere length between young and aged MuSCs from uninjured wild-type mice, but MuSCs isolated from young dystrophic mice exhibited significantly shortened telomeres. In corroboration, we demonstrated that telomere attrition is present in human dystrophic MuSCs, which underscores its importance in diseased regenerative failure. The robust technique described herein provides analysis at a single-cell resolution and may be utilized for other cell types, especially rare populations of cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.