Evidence map›Paper›PMID 28890156›Full record

ArticleBrain, behavior, and immunity2018

The microbiota influences cell death and microglial colonization in the perinatal mouse brain.

Alexandra Castillo-Ruiz, Morgan Mosley, Arlene J George, Lamiyah F Mussaji, Evan F Fullerton, Elara M Ruszkowski, Andrew J Jacobs, Andrew T Gewirtz, Benoit Chassaing, Nancy G Forger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 85 citations in OpenAlex.

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  20. Microglia and Microbiome-Gut-Brain Axis.Advances in neurobiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Alexandra Castillo-RuizNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA. Electronic address: acastilloruiz@gsu.edu.
Morgan MosleyNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Arlene J GeorgeNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Lamiyah F MussajiNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Evan F FullertonNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Elara M RuszkowskiNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Andrew J JacobsNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Andrew T GewirtzCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Benoit ChassaingCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Nancy G ForgerNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Georgia State University · US

Funding

Microbiota and Neural Circuits controlling Social BehaviorR21MH108345 · NIMH · GEORGIA STATE UNIVERSITY · PI DE VRIES, GEERT J., FORGER, NANCY G · 2016 to 2017
$416k
NIMH NIH HHS R21 MH108345
6 · The paper itself

Abstract

The mammalian fetus develops in a largely sterile environment, and direct exposure to a complex microbiota does not occur until birth. We took advantage of this to examine the effect of the microbiota on brain development during the first few days of life. The expression of anti- and pro-inflammatory cytokines, developmental cell death, and microglial colonization in the brain were compared between newborn conventionally colonized mice and mice born in sterile, germ-free (GF) conditions. Expression of the pro-inflammatory cytokines interleukin 1β and tumor necrosis factor α was markedly suppressed in GF newborns. GF mice also had altered cell death, with some regions exhibiting higher rates (paraventricular nucleus of the hypothalamus and the CA1 oriens layer of the hippocampus) and other regions exhibiting no change or lower rates (arcuate nucleus of the hypothalamus) of cell death. Microglial labeling was elevated in GF mice, due to an increase in both microglial cell size and number. The changes in cytokine expression, cell death and microglial labeling were evident on the day of birth, but were absent on embryonic day 18.5, approximately one-half day prior to expected delivery. Taken together, our results suggest that direct exposure to the microbiota at birth influences key neurodevelopmental events and does so within hours. These findings may help to explain some of the behavioral and neurochemical alterations previously seen in adult GF mice.

Indexed as

Cell DeathMicrobiotaAnimalsBrainEncephalitisFemaleInflammation MediatorsMaleMiceMicrogliaNeuronsPregnancyInflammation MediatorsActivated caspase 3Arcuate nucleusCA1 oriensCytokinesGerm-freeIba1NeonatalParaventricular nucleusPrenatal

Identifiers

PMID28890156
PMCPMC5696094
OpenAlexW2753781001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.