ArticleNeurotoxicology2017
Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-BPA consortium study.
Article in Neurotoxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Sex-specific disruption of estrogen receptor alpha (ERα) density in the social brain neural network by Firemaster 550.Journal of the Endocrine Society · 2026Article
- Endocrine-disrupting effects of bisphenol-A, thiamethoxam, and fipronil in hormone-naïve transmen compared to cis-women.Hormones (Athens, Greece) · 2024Article
- Gestational bisphenol A exposure alters energy homeostasis and adult hypothalamic neurogenesis in female mice.Scientific reports · 2024Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic Microglia Numbers, Ramification, and Phagocytic Cups.Frontiers in neuroscience · 2022Article
- Transgenerational effects of polychlorinated biphenyls: 2. Hypothalamic gene expression in rats†.Biology of reproduction · 2021Article
- Gestational low-dose BPA exposure impacts suprachiasmatic nucleus neurogenesis and circadian activity with transgenerational effects.Science advances · 2021Article
- Comparative Neurodevelopment Effects of Bisphenol A and Bisphenol F on Rat Fetal Neural Stem Cell Models.Cells · 2021Article
- Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- The Use and Misuse of Historical Controls in Regulatory Toxicology: Lessons from the CLARITY-BPA Study.Endocrinology · 2020Article
- Achieving CLARITY on bisphenol A, brain and behaviour.Journal of neuroendocrinology · 2020Review
- Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study.Neurotoxicology · 2019Article
- CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems.Basic & clinical pharmacology & toxicology · 2019Review
- Endocrine disruptors and the future of toxicology testing - lessons from CLARITY-BPA.Nature reviews. Endocrinology · 2019Review
- Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior.Hormones and behavior · 2019Review
- Neuro-toxic and Reproductive Effects of BPA.Current neuropharmacology · 2019Review
- IR-MALDESI mass spectrometry imaging of underivatized neurotransmitters in brain tissue of rats exposed to tetrabromobisphenol A.Analytical and bioanalytical chemistry · 2018Article
- Replacement Bisphenols Adversely Affect Mouse Gametogenesis with Consequences for Subsequent Generations.Current biology : CB · 2018Article
- Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study.Neurotoxicology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bisphenol A (BPA) is a high volume endocrine disrupting chemical found in a wide variety of products including plastics and epoxy resins. Human exposure is nearly ubiquitous, and higher in children than adults. Because BPA has been reported to interfere with sex steroid hormone signaling, there is concern that developmental exposure, even at levels below the current FDA No Observed Adverse Effect Level (NOAEL) of 5mg/kg body weight (bw)/day, can disrupt brain sexual differentiation. The current studies were conducted as part of the CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) program and tested the hypothesis that perinatal BPA exposure would induce morphological changes in hormone sensitive, sexually dimorphic brain regions. Sprague-Dawley rats were randomly assigned to 5 groups: BPA (2.5, 25, or 2500μg/kgbw/day), a reference estrogen (0.5μg ethinylestradiol (EE
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.